NAGIOS: RODERIC FUNCIONANDO

ID4 is required for normal ependymal cell development

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ID4 is required for normal ependymal cell development

dc.contributor.author	Rocamonde, Brenda
dc.contributor.author	Herranz Pérez, Vicente
dc.contributor.author	García Verdugo, José Manuel
dc.contributor.author	Huillard, Emmanuelle
dc.date.accessioned	2022-04-12T12:57:25Z
dc.date.available	2022-04-12T12:57:25Z
dc.date.issued	2021
dc.identifier.citation	Rocamonde, Brenda Herranz Pérez, Vicente García Verdugo, José Manuel Huillard, Emmanuelle 2021 ID4 is required for normal ependymal cell development Frontiers In Neuroscience 15 668243 1 7
dc.identifier.uri	https://hdl.handle.net/10550/82313
dc.description.abstract	Ependymal cells are radial glia-derived multiciliated cells lining the lateral ventricles of the brain and spinal cord. Correct development and coordinated cilia beating is essential for proper cerebrospinal fluid (CSF) flow and neurogenesis modulation. Dysfunctions of ependymal cells were associated with transcription factor deregulation. Here we provide evidence that the transcriptional regulator ID4 is involved in ependymal cell development and maturation. We observed that Id4-deficient mice display altered ventricular cell cytoarchitecture, decreased ependymal cell number and enlarged ventricles. In addition, absence of ID4 during embryonic development resulted in decreased ependymal cell number and delayed maturation. Our findings open the way for a potential role of ID4 in ependymal cell development and motor cilia function.
dc.language.iso	eng
dc.relation.ispartof	Frontiers In Neuroscience, 2021, vol. 15, num. 668243, p. 1-7
dc.subject	Cèl·lules
dc.subject	Neurociències
dc.title	ID4 is required for normal ependymal cell development
dc.type	journal article	es_ES
dc.date.updated	2022-04-12T12:57:25Z
dc.identifier.doi	10.3389/fnins.2021.668243
dc.identifier.idgrec	151440
dc.rights.accessRights	open access	es_ES