With the development of technological innovations, Big Data is transforming the socio-economic world, impacting almost every organization and person. The transformations associated with the development of Big Data have important consequences for the sustainability of organizations, regions, and the society as a whole, and as such, they have been specifically addressed by the academic literature focusing on sustainability. Despite its importance, and perhaps because of its rapid emergence, there is a lack of studies dealing with the analysis of this body of literature and its trends. The current research attempts to fill this gap. The study develops a bibliometric and visualization analysis of the literature on the nexus between Big Data and Sustainability. The research analyzes 726 documents on this topic, published until the end of 2020, in the Web of Science Core Collection database through the VOSviewer software. The results indicate the main trends and developments on the topic related to the most cited papers, authors, publications, institutions, and countries. The visualized frameworks, structures and trends are useful for both researchers and practitioners, as they can help them understand the current situation, issues to consider, and main developments on the topic.