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Histone post-translational modifications as potential therapeutic targets for pain management

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Histone post-translational modifications as potential therapeutic targets for pain management

dc.contributor.author	Torres-Perez, Jose V.
dc.contributor.author	Irfan, Jahanzaib
dc.contributor.author	Febrianto, Muhammad Rizki
dc.contributor.author	Di Giovanni, Simone
dc.contributor.author	Nagy, Istvan
dc.date.accessioned	2022-04-27T14:51:23Z
dc.date.available	2022-04-27T14:51:23Z
dc.date.issued	2021
dc.identifier.citation	Torres-Perez, Jose V. Irfan, Jahanzaib Febrianto, Muhammad Rizki Di Giovanni, Simone Nagy, Istvan 2021 Histone post-translational modifications as potential therapeutic targets for pain management Trends in Pharmacological Sciences 42 11 897 911
dc.identifier.uri	https://hdl.handle.net/10550/82437
dc.description.abstract	Effective pharmacological management of pain associated with tissue pathology is an unmet medical need. Transcriptional modifications in nociceptive pathways are pivotal for the development and the maintenance of pain associated with tissue damage. Accumulating evidence has shown the importance of the epigenetic control of transcription in nociceptive pathways via histone post-translational modifications (PTMs). Hence, histone PTMs could be targets for novel effective analgesics. Here, we discuss the current understanding of histone PTMs in the modulation of gene expression affecting nociception and pain phenotypes following tissue injury. We also provide a critical view of the translational implications of preclinical models and discuss opportunities and challenges of targeting histone PTMs to relieve pain in clinically relevant tissue injuries.
dc.language.iso	eng
dc.relation.ispartof	Trends in Pharmacological Sciences, 2021, vol. 42, num. 11, p. 897-911
dc.subject	Farmacologia
dc.subject	Genètica
dc.title	Histone post-translational modifications as potential therapeutic targets for pain management
dc.type	journal article	es_ES
dc.date.updated	2022-04-27T14:51:24Z
dc.identifier.doi	10.1016/j.tips.2021.08.002
dc.identifier.idgrec	151949
dc.rights.accessRights	open access	es_ES