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Stress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (Danio rerio)

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Stress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (Danio rerio)

dc.contributor.author	Evans, James R.
dc.contributor.author	Torres-Perez, Jose V.
dc.contributor.author	Miletto Petrazzini, Maria Elena
dc.contributor.author	Riley, Riva
dc.contributor.author	Brennan, Caroline H.
dc.date.accessioned	2022-04-29T14:12:37Z
dc.date.available	2022-04-29T14:12:37Z
dc.date.issued	2021
dc.identifier.citation	Evans, James R. Torres-Perez, Jose V. Miletto Petrazzini, Maria Elena Riley, Riva Brennan, Caroline H. 2021 Stress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (Danio rerio) Scientific Reports 11 339 1 11
dc.identifier.uri	https://hdl.handle.net/10550/82472
dc.description.abstract	Individual differences in personality are associated with variation in healthy aging. Health behaviours are often cited as the likely explanation for this association; however, an underlying biological mechanism may also exist. Accelerated leukocyte telomere shortening is implicated in multiple age-related diseases and is associated with chronic activation of the hypothalamus-pituitary-adrenal (HPA) axis, providing a link between stress-related personality differences and adverse health outcomes. However, the effects of the HPA axis are tissue specific. Thus, leukocyte telomere length may not accurately reflect telomere length in disease-relevant tissues. Here, we examined the correlation between stress reactivity and telomere length in heart and brain tissue in young (6-9 month) and aging (18 month) zebrafish. Stress reactivity was assessed by tank diving and through gene expression. Telomere length was assessed using quantitative PCR. We show that aging zebrafish have shorter telomeres in both heart and brain. Telomere length was inversely related to stress reactivity in heart but not brain of aging individuals. These data support the hypotheses that an anxious predisposition contributes to accelerated telomere shortening in heart tissue, which may have important implications for our understanding of age-related heart disease, and that stress reactivity contributes to age-related telomere shortening in a tissue-specific manner.
dc.language.iso	eng
dc.relation.ispartof	Scientific Reports, 2021, vol. 11, num. 339, p. 1-11
dc.subject	Biologia
dc.subject	Estrès
dc.title	Stress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (Danio rerio)
dc.type	journal article	es_ES
dc.date.updated	2022-04-29T14:12:37Z
dc.identifier.doi	10.1038/s41598-020-79615-1
dc.identifier.idgrec	152090
dc.rights.accessRights	open access	es_ES