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In Vitro Evaluation of the Biological Effects of ACTIVA Kids BioACTIVE Restorative, Ionolux, and Riva Light Cure on Human Dental Pulp Stem Cells

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In Vitro Evaluation of the Biological Effects of ACTIVA Kids BioACTIVE Restorative, Ionolux, and Riva Light Cure on Human Dental Pulp Stem Cells

dc.contributor.author	López-García, Sergio
dc.contributor.author	Pecci-Lloret, María P.
dc.contributor.author	Pecci-Lloret, Miguel R.
dc.contributor.author	Oñate Sánchez, Ricardo Elías
dc.contributor.author	García-Bernal, David
dc.contributor.author	Castelo Baz, Pablo
dc.contributor.author	Rodríguez Lozano, Francisco Javier
dc.contributor.author	Guerrero Gironés, Julia
dc.date.accessioned	2022-05-09T08:47:57Z
dc.date.available	2022-05-09T08:47:57Z
dc.date.issued	2019
dc.identifier.citation	López-García, Sergio Pecci-Lloret, María P. Pecci-Lloret, Miguel R. Oñate Sánchez, Ricardo Elías García-Bernal, David Castelo Baz, Pablo Rodríguez Lozano, Francisco Javier Guerrero Gironés, Julia 2019 In Vitro Evaluation of the Biological Effects of ACTIVA Kids BioACTIVE Restorative, Ionolux, and Riva Light Cure on Human Dental Pulp Stem Cells Materials
dc.identifier.uri	https://hdl.handle.net/10550/82668
dc.description.abstract	This study aimed to analyze the biological effects of three new bioactive materials on cell survival, migration, morphology, and attachment in vitro. ACTIVA Kids BioACTIVE Restorative (Pulpdent, Watertown, MA, USA) (Activa), Ionolux (Voco, Cuxhaven, Germany), and Riva Light Cure UV (SDI, Bayswater, Australia) (Riva) were handled and conditioned with a serum-free culture medium. Stem cells from human dental pulp (hDPSCs) were exposed to material extracts, and metabolic activity, cell migration, and cell morphology were evaluated. Cell adhesion to the different materials was analyzed by scanning electron microscopy (SEM). The chemical composition of the materials was evaluated by energy-dispersive X-ray (EDX). One-way analysis of variance followed by a Tukey test was performed (p < 0.05). Ionolux promoted a drastic reduction in metabolic activity and wound closure compared to the control (p < 0.05), whereas Activa induced adequate metabolic activity and cell migration. Moreover, SEM and immunofluorescence analysis showed abundant cells exposed to Activa. The materials showed different surface morphologies, and EDX spectra exhibited different peaks of C, O, Si, S, Ca, and F ions in glass ionomer cements. The results showed that Activa induced cell migration, cell attachment, and cell viability to a greater extent than Riva and Ionolux.
dc.language.iso	eng
dc.relation.ispartof	Materials, 2019
dc.subject	Odontologia
dc.title	In Vitro Evaluation of the Biological Effects of ACTIVA Kids BioACTIVE Restorative, Ionolux, and Riva Light Cure on Human Dental Pulp Stem Cells
dc.type	journal article	es_ES
dc.date.updated	2022-05-09T08:47:57Z
dc.identifier.doi	10.3390/ma12223694
dc.identifier.idgrec	152503
dc.rights.accessRights	open access	es_ES