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Role of the Non-Canonical RNAi Pathway in the Antifungal Resistance and Virulence of Mucorales

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Role of the Non-Canonical RNAi Pathway in the Antifungal Resistance and Virulence of Mucorales

dc.contributor.author	Cánovas Márquez, José Tomás
dc.contributor.author	Navarro Mendoza, María Isabel
dc.contributor.author	Pérez Arques, Carlos
dc.contributor.author	Lax Molina, Carlos
dc.contributor.author	Tahiri, Ghizlane
dc.contributor.author	Pérez Ruiz, José Antonio
dc.contributor.author	Lorenzo Gutiérrez, Damaris
dc.contributor.author	Calo, Silvia
dc.contributor.author	López-García, Sergio
dc.contributor.author	Navarro, Eusebio
dc.contributor.author	Nicolás, Francisco Esteban
dc.contributor.author	Garre, Victoriano
dc.contributor.author	Murcia Flores, Laura
dc.date.accessioned	2022-05-09T14:27:46Z
dc.date.available	2022-05-09T14:27:46Z
dc.date.issued	2021
dc.identifier.citation	Cánovas Márquez, José Tomás Navarro Mendoza, María Isabel Pérez Arques, Carlos Lax Molina, Carlos Tahiri, Ghizlane Pérez Ruiz, José Antonio Lorenzo Gutiérrez, Damaris Calo, Silvia López-García, Sergio Navarro, Eusebio Nicolás, Francisco Esteban Garre, Victoriano Murcia Flores, Laura 2021 Role of the Non-Canonical RNAi Pathway in the Antifungal Resistance and Virulence of Mucorales Genes
dc.identifier.uri	https://hdl.handle.net/10550/82673
dc.description.abstract	Mucorales are the causal agents for the lethal disease known as mucormycosis. Mortality rates of mucormycosis can reach up to 90%, due to the mucoralean antifungal drug resistance and the lack of effective therapies. A concerning urgency among the medical and scientific community claims to find targets for the development of new treatments. Here, we reviewed different studies describing the role and machinery of a novel non-canonical RNAi pathway (NCRIP) only conserved in Mucorales. Its non-canonical features are the independence of Dicer and Argonaute proteins. Conversely, NCRIP relies on RNA-dependent RNA Polymerases (RdRP) and an atypical ribonuclease III (RNase III). NCRIP regulates the expression of mRNAs by degrading them in a specific manner. Its mechanism binds dsRNA but only cuts ssRNA. NCRIP exhibits a diversity of functional roles. It represses the epimutational pathway and the lack of NCRIP increases the generation of drug resistant strains. NCRIP also regulates the control of retrotransposons expression, playing an essential role in genome stability. Finally, NCRIP regulates the response during phagocytosis, affecting the multifactorial process of virulence. These critical NCRIP roles in virulence and antifungal drug resistance, along with its exclusive presence in Mucorales, mark this pathway as a promising target to fight against mucormycosis.
dc.language.iso	eng
dc.relation.ispartof	Genes, 2021
dc.subject	Fongs
dc.subject	Infecció
dc.title	Role of the Non-Canonical RNAi Pathway in the Antifungal Resistance and Virulence of Mucorales
dc.type	journal article	es_ES
dc.date.updated	2022-05-09T14:27:46Z
dc.identifier.doi	10.3390/genes12040586
dc.identifier.idgrec	152512
dc.rights.accessRights	open access	es_ES