NAGIOS: RODERIC FUNCIONANDO

In Vitro Biocompatibility of Several Children's Toothpastes on Human Gingival Fibroblasts

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

In Vitro Biocompatibility of Several Children's Toothpastes on Human Gingival Fibroblasts

dc.contributor.author	Pecci-Lloret, María P.
dc.contributor.author	López-García, Sergio
dc.contributor.author	Rodríguez Lozano, Francisco Javier
dc.contributor.author	Álvarez Nóvoa, Pablo
dc.contributor.author	García-Bernal, David
dc.date.accessioned	2022-05-09T15:08:53Z
dc.date.available	2022-05-09T15:08:53Z
dc.date.issued	2022
dc.identifier.citation	Pecci-Lloret, María P. López-García, Sergio Rodríguez Lozano, Francisco Javier Álvarez Nóvoa, Pablo García-Bernal, David 2022 In Vitro Biocompatibility of Several Children's Toothpastes on Human Gingival Fibroblasts International Journal Of Environmental Research And Public Health
dc.identifier.uri	https://hdl.handle.net/10550/82674
dc.description.abstract	The European Academy of Paediatric Dentistry has recommended fluoride toothpastes from the eruption of the first teeth in children. Toothpastes stay in the mouth in contact with human gingival fibroblasts (hGFs) for a long time. Thus, the objective of this study was to compare the cytotoxicity of five different commonly used children's toothpastes: Oral B Kids +3 (Procter & Gamble, Alicante, Spain), Fluor Kin Calcium (Kin, Madrid, Spain), PHB Junior (PHB, Barcelona, Spain), Colgate +3 (Colgate Palmolive, Madrid, Spain) and Vitis Kids (Dentaid, Valencia, Spain) on hGFs. The children's toothpastes were exposed to hGFs at different concentrations (1:1, 1:2, 1:4). Afterwards, several tests were performed: MTT assays, cell cycle analyses, cell cytoskeleton staining assays, apoptosis/necrosis assays, and ICP-MS and ion chromatography. Oral B displayed the lowest cytotoxicity and was the toothpaste with the highest fluoride ion release; meanwhile, the other toothpastes were cytotoxic (*** p < 0.0001); Fluor Kin being the one with the lowest fluoride ion release. Among all the toothpastes analyzed, Oral B exhibited the best results in vitro in terms of biocompatibility. Future evaluations, both in vitro and in vivo, are required to confirm the biocompatibility of sodium lauryl sarcosinate and sodium lauryl sulfate containing toothpastes.
dc.language.iso	eng
dc.relation.ispartof	International Journal Of Environmental Research And Public Health, 2022
dc.subject	Odontologia
dc.subject	Dents
dc.title	In Vitro Biocompatibility of Several Children's Toothpastes on Human Gingival Fibroblasts
dc.type	journal article	es_ES
dc.date.updated	2022-05-09T15:08:55Z
dc.identifier.doi	10.3390/ijerph19052954
dc.identifier.idgrec	152513
dc.rights.accessRights	open access	es_ES