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Chemical aspects of human and environmental overload with fluorine

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Chemical aspects of human and environmental overload with fluorine

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dc.contributor.author	Han, Jianlin
dc.contributor.author	Kiss, Loránd
dc.contributor.author	Mei, Haibo
dc.contributor.author	Remete, Attila Márió
dc.contributor.author	Ponikvar-Svet, Maja
dc.contributor.author	Sedgwick, Daniel Mark
dc.contributor.author	Roman, Raquel
dc.contributor.author	Fustero Lardiés, Santos
dc.contributor.author	Moriwaki, Hiroki
dc.contributor.author	Soloshonok, Vadim A.
dc.date.accessioned	2022-05-10T13:55:33Z
dc.date.available	2022-05-10T13:55:33Z
dc.date.issued	2021
dc.identifier.citation	Han, Jianlin Kiss, Loránd Mei, Haibo Remete, Attila Márió Ponikvar-Svet, Maja Sedgwick, Daniel Mark Roman, Raquel Fustero Lardiés, Santos Moriwaki, Hiroki Soloshonok, Vadim A. 2021 Chemical aspects of human and environmental overload with fluorine Chemical Reviews 121 8 4678 4742
dc.identifier.uri	https://hdl.handle.net/10550/82708
dc.description.abstract	Over the last 100−120 years, due to the ever-increasing importance of fluorine-containing compounds in modern technology and daily life, the explosive development of the fluorochemical industry led to an enormous increase of emission of fluoride ions into the biosphere. This made it more and more important to understand the biological activities, metabolism, degradation, and possible environmental hazards of such substances. This comprehensive and critical review focuses on the effects of fluoride ions and organofluorine compounds (mainly pharmaceuticals and agrochemicals) on human health and the environment. To give a better overview, various connected topics are also discussed: reasons and trends of the advance of fluorine-containing pharmaceuticals and agrochemicals, metabolism of fluorinated drugs, withdrawn fluorinated drugs, natural sources of organic and inorganic fluorine compounds in the environment (including the biosphere), sources of fluoride intake, and finally biomarkers of fluoride exposure.
dc.language.iso	eng
dc.relation.ispartof	Chemical Reviews, 2021, vol. 121, num. 8, p. 4678-4742
dc.subject	Química farmacèutica
dc.subject	Pèptids
dc.title	Chemical aspects of human and environmental overload with fluorine
dc.type	journal article	es_ES
dc.date.updated	2022-05-10T13:55:34Z
dc.identifier.doi	10.1021/acs.chemrev.0c01263
dc.identifier.idgrec	152644
dc.rights.accessRights	open access	es_ES