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ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex

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ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex

dc.contributor.author	Medeiros de Araújo, Jéssica Alves
dc.contributor.author	Barão, Soraia
dc.contributor.author	Mateos-White, Isabel
dc.contributor.author	Espinosa, Ana
dc.contributor.author	Costa, Marcos R.
dc.contributor.author	Gil-Sanz, Cristina
dc.contributor.author	Müller, Ulrich
dc.date.accessioned	2022-05-13T17:13:01Z
dc.date.available	2022-08-19T04:45:06Z
dc.date.issued	2021
dc.identifier.citation	Medeiros de Araújo, Jéssica Alves Barão, Soraia Mateos-White, Isabel Espinosa, Ana Costa, Marcos R. Gil-Sanz, Cristina Mu&#776ller, Ulrich 2021 ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex Development 148 16 dev196642
dc.identifier.uri	https://hdl.handle.net/10550/82771
dc.description.abstract	Neocortical progenitor cells generate subtypes of excitatory projection neurons in sequential order followed by the generation of astrocytes. The transcription factor zinc finger and BTB domain-containing protein 20 (ZBTB20) has been implicated in regulation of cell specification during neocortical development. Here, we show that ZBTB20 instructs the generation of a subset of callosal projections neurons in cortical layers II/III in mouse. Conditional deletion of Zbtb20 in cortical progenitors, and to a lesser degree in differentiating neurons, leads to an increase in the number of layer IV neurons at the expense of layer II/III neurons. Astrogliogenesis is also affected in the mutants with an increase in the number of a specific subset of astrocytes expressing GFAP. Astrogliogenesis is more severely disrupted by a ZBTB20 protein containing dominant mutations linked to Primrose syndrome, suggesting that ZBTB20 acts in concert with other ZBTB proteins that were also affected by the dominant-negative protein to instruct astrogliogenesis. Overall, our data suggest that ZBTB20 acts both in progenitors and in postmitotic cells to regulate cell fate specification in the mammalian neocortex.
dc.language.iso	eng
dc.relation.ispartof	Development, 2021, vol. 148, num. 16, p. dev196642
dc.subject	Neurones
dc.subject	Cèl·lules
dc.title	ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex
dc.type	journal article	es_ES
dc.date.updated	2022-05-13T17:13:03Z
dc.identifier.doi	10.1242/dev.196642
dc.identifier.idgrec	153045
dc.embargo.terms	1 year
dc.rights.accessRights	open access	es_ES