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Mitochondrial DNA replacement techniques to prevent human mitochondrial diseases

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Mitochondrial DNA replacement techniques to prevent human mitochondrial diseases

dc.contributor.author	Sendra Gisbert, Luis
dc.contributor.author	García-Mares, Alfredo
dc.contributor.author	Herrero Cervera, María José
dc.contributor.author	Aliño Pellicer, Salvador F.
dc.date.accessioned	2022-05-18T13:59:03Z
dc.date.available	2022-05-18T13:59:03Z
dc.date.issued	2021
dc.identifier.citation	Sendra Gisbert, Luis García-Mares, Alfredo Herrero Cervera, María José Aliño Pellicer, Salvador F. 2021 Mitochondrial DNA replacement techniques to prevent human mitochondrial diseases International Journal Of Molecular Sciences 22 2 551
dc.identifier.uri	https://hdl.handle.net/10550/82831
dc.description.abstract	Background: Mitochondrial DNA (mtDNA) diseases are a group of maternally inherited genetic disorders caused by a lack of energy production. Currently, mtDNA diseases have a poor prognosis and no known cure. The chance to have unaffected offspring with a genetic link is important for the affected families, and mitochondrial replacement techniques (MRTs) allow them to do so. MRTs consist of transferring the nuclear DNA from an oocyte with pathogenic mtDNA to an enucleated donor oocyte without pathogenic mtDNA. This paper aims to determine the efficacy, associated risks, and main ethical and legal issues related to MRTs. Methods: A bibliographic review was performed on the MEDLINE and Web of Science databases, along with searches for related clinical trials and news. Results: A total of 48 publications were included for review. Five MRT procedures were identified and their efficacy was compared. Three main risks associated with MRTs were discussed, and the ethical views and legal position of MRTs were reviewed. Conclusions: MRTs are an effective approach to minimizing the risk of transmitting mtDNA diseases, but they do not remove it entirely. Global legal regulation of MRTs is required.
dc.language.iso	eng
dc.relation.ispartof	International Journal Of Molecular Sciences, 2021, vol. 22, num. 2, p. 551
dc.subject	Mitocondris
dc.subject	Farmacologia
dc.title	Mitochondrial DNA replacement techniques to prevent human mitochondrial diseases
dc.type	journal article	es_ES
dc.date.updated	2022-05-18T13:59:03Z
dc.identifier.doi	10.3390/ijms22020551
dc.identifier.idgrec	152198
dc.rights.accessRights	open access	es_ES