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IgA-Dominant Infection-Associated Glomerulonephritis Following SARS-CoV-2 Infection

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IgA-Dominant Infection-Associated Glomerulonephritis Following SARS-CoV-2 Infection

dc.contributor.author	Pérez, Aurora
dc.contributor.author	Torregrosa Maicas, Isidro Antonio
dc.contributor.author	D'Marco, Luis
dc.contributor.author	Juan, Isabel
dc.contributor.author	Terradez Más, Liria
dc.contributor.author	Solís Salguero, Miguel Ángel
dc.contributor.author	Moncho, Francesc
dc.contributor.author	Carda Batalla, Maria del Carmen
dc.contributor.author	Forner, Maria J.
dc.contributor.author	Górriz Teruel, Jose Luis
dc.date.accessioned	2022-06-15T11:52:54Z
dc.date.available	2022-06-15T11:52:54Z
dc.date.issued	2021
dc.identifier.citation	Pérez, Aurora Torregrosa Maicas, Isidro Antonio D'Marco, Luis Juan, Isabel Terradez Más, Liria Solís Salguero, Miguel Ángel Moncho, Francesc Carda Batalla, Maria del Carmen Forner, Maria J. Gorriz Teruel, Jose Luis 2021 IgA-Dominant Infection-Associated Glomerulonephritis Following SARS-CoV-2 Infection Viruses 13 4 587 591
dc.identifier.uri	https://hdl.handle.net/10550/83155
dc.description.abstract	The renal involvement of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) has been reported. The etiology of kidney injury appears to be tubular, mainly due to the expression of angiotensin-converting enzyme 2, the key joint receptor for SARS-CoV-2; however, cases with glomerular implication have also been documented. The multifactorial origin of this renal involvement could include virus-mediated injury, cytokine storm, angiotensin II pathway activation, complement dysregulation, hyper-coagulation, and microangiopathy. We present the renal histological findings from a patient who developed acute kidney injury and de novo nephrotic syndrome, highly suggestive of acute IgA-dominant infection-associated glomerulonephritis (IgADIAGN) after SARS-CoV-2 infection, as evidenced by the presence of this virus detected in the renal tissue of the patient via immunohistochemistry assay. In summary, we document the first case of IgA-DIAGN associated to SARS-CoV-2. Thus, SARS-CoV-2 S may act as a super antigen driving the development of multisystem inflammatory syndrome as well as cytokine storm in patients affected by COVID-19, reaching the glomerulus and leading to the development of this novel IgA-DIAGN.
dc.language.iso	eng
dc.relation.ispartof	Viruses, 2021, vol. 13, num. 4, p. 587-591
dc.subject	Virus
dc.title	IgA-Dominant Infection-Associated Glomerulonephritis Following SARS-CoV-2 Infection
dc.type	journal article	es_ES
dc.date.updated	2022-06-15T11:52:54Z
dc.identifier.doi	10.3390/v13040587
dc.identifier.idgrec	154205
dc.rights.accessRights	open access	es_ES