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Cardiovascular risk factors and the impact on prognosis in patients with chronic kidney disease secondary to autosomal dominant polycystic kidney disease

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Cardiovascular risk factors and the impact on prognosis in patients with chronic kidney disease secondary to autosomal dominant polycystic kidney disease

dc.contributor.author	Górriz Teruel, Jose Luis
dc.contributor.author	Arroyo, David
dc.contributor.author	D'Marco, Luis
dc.contributor.author	Torra, Roser
dc.contributor.author	Tomás Simó, Patricia
dc.contributor.author	Puchades Montesa, María Jesús
dc.contributor.author	Panizo González, Nayara
dc.contributor.author	Pantoja, Jonay
dc.contributor.author	Montomoli, Marco
dc.contributor.author	Llisterri, José Luis
dc.contributor.author	Pallarés Carratalá, Vicente J.
dc.contributor.author	Valdivielso, Jose Manuel
dc.date.accessioned	2022-06-15T17:38:54Z
dc.date.available	2022-06-15T17:38:54Z
dc.date.issued	2021
dc.identifier.citation	Górriz Teruel, Jose Luis Arroyo, David D'Marco, Luis Torra, Roser Tomás Simó, Patricia Puchades Montesa, María Jesús Panizo González, Nayara Pantoja, Jonay Montomoli, Marco Llisterri, José Luis Pallarés Carratalá, Vicente J. Valdivielso, Jose Manuel 2021 Cardiovascular risk factors and the impact on prognosis in patients with chronic kidney disease secondary to autosomal dominant polycystic kidney disease Bmc Nephrology
dc.identifier.uri	https://hdl.handle.net/10550/83166
dc.description.abstract	Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent hereditary renal disease. There is an increased rate of cardiovascular disease (CVD) in ADPKD. In this study, we evaluate the prevalence of cardiovascular risk factors, the achievement rates for treatment goals and cardiovascular events (CVE) in ADPKD and their relations with asymptomatic CVD in CKD from other etiologies (CKDoe) and controls. Methods: We evaluated 2445 CKD patients (2010-2012). The information collected was: clinical, anthropometric and analytical parameters, treatments and CVD evaluation (intima-media thickness (IMT), atheromatous plaque presence and ankle-brachial index (ABI)). Laboratory, vital status, CVE and hospitalizations were collected for 4 years. Results: ADPKD patients had a worse renal function and worst achievement of blood pressure, higher parathormone levels but lower proteinuria compared to CKDoe. ADPKD patients presented lower IMT values than other groups, however, an intermediate rate of pathologic ABI and atheromatous plaque was present. More than half of the patients received statins, achieving LDL-c levels < 100 only in 50 and 39.8% of them (ADPKD and CKDoe respectively). The number of CVE during the follow-up period was low. In adjusted Cox regression model, ADPDK had the lowest occurrence of CVE of all three groups (HR:0.422, 95%CI 0.221-0.808, p = 0.009). Conclusion: ADPKD patients show intermediate control rates of CVD. A better control of CVD risk seems to be related with a lower load of CVD compared to other groups, which may lead in the long term to a better prognosis. Further investigation is necessary to determine cardiovascular prognosis in ADPKD.
dc.language.iso	eng
dc.relation.ispartof	Bmc Nephrology, 2021
dc.subject	Cor Malalties
dc.subject	Insuficiència renal crònica
dc.title	Cardiovascular risk factors and the impact on prognosis in patients with chronic kidney disease secondary to autosomal dominant polycystic kidney disease
dc.type	journal article	es_ES
dc.date.updated	2022-06-15T17:38:54Z
dc.identifier.doi	10.1186/s12882-021-02313-1
dc.identifier.idgrec	154204
dc.rights.accessRights	open access	es_ES