Almost all the recent studies addressing road safety from the approach of human factors agree that stress is one of the most considerable (but underestimated) threats for safe driving. However, evidence on the relationship between stressful life events and driver performance remains scarce. Therefore, this study aimed to assess life stress-related perceptions of Spanish drivers, as well as exploring their relationships with self-reported driving performance, decision-making and other road safety-related issues. Methods: This cross-sectional research analysed the information gathered from a nationwide sample of n=840 Spanish drivers responding to an electronic survey on psychosocial issues, stress-related factors and driving issues. The results show that a high percentage (75%) consider that stress may impair their driving performance, while 76.9% of drivers report having experienced at least one major stressful life event during the last year. Despite this relatively high awareness of the negative role of stress and its associated factors for driving safety, this study found that drivers tend to 'ignore the alarm signals', as they often reported keeping driving, even when noticing their driving fitness and performance might be impaired by stress-related factors. This study highlights the need to create and apply interventions aimed at informing and training drivers to identify, manage and cope with stress from different spheres, including stressful life events, as a means of potentially improving their driving safety habits and outcomes