NAGIOS: RODERIC FUNCIONANDO

Nucleo-cytoplasmic shuttling of RNA-binding factors: mRNA buffering and beyond

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Nucleo-cytoplasmic shuttling of RNA-binding factors: mRNA buffering and beyond

Mostra el registre parcial de l'element

dc.contributor.author Pérez Ortín, José Enrique
dc.contributor.author Chávez, Sebastián
dc.date.accessioned 2022-08-30T08:56:41Z
dc.date.available 2022-08-30T08:56:41Z
dc.date.issued 2022
dc.identifier.citation Pérez Ortín, José Enrique Chávez, Sebastián 2022 Nucleo-cytoplasmic shuttling of RNA-binding factors: mRNA buffering and beyond Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms 1865 194849
dc.identifier.uri https://hdl.handle.net/10550/83570
dc.description.abstract Gene expression is a highly regulated process that adapts RNAs and proteins content to the cellular context. Under steady-state conditions, mRNA homeostasis is robustly maintained by tight controls that act on both nuclear transcription and cytoplasmic mRNA stability. In recent years, it has been revealed that several RNA-binding proteins (RBPs) that perform functions in mRNA decay can move to the nucleus and regulate transcription. The RBPs involved in transcription can also travel to the cytoplasm and regulate mRNA degradation and/or translation. The multifaceted functions of these shuttling nucleo-cytoplasm RBPs have raised the possibility that they can act as mRNA metabolism coordinators. In addition, this indicates the existence of crosstalk mechanisms between the enzymatic machineries that drive the different mRNA life-cycle phases. The buffering of the mRNA concentration is the best known consequence of a transcription-degradation crosstalk counteraction, but alternative ways of RBP action can also imply enhanced gene regulation.
dc.language.iso eng
dc.relation.ispartof Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 2022, vol. 1865, p. 194849
dc.subject Interaccions RNA-proteïna
dc.subject Transcripció genètica
dc.title Nucleo-cytoplasmic shuttling of RNA-binding factors: mRNA buffering and beyond
dc.type journal article es_ES
dc.date.updated 2022-08-30T08:56:41Z
dc.identifier.doi 10.1016/j.bbagrm.2022.194849
dc.identifier.idgrec 154565
dc.rights.accessRights open access es_ES

Visualització       (753.5Kb)

Aquest element apareix en la col·lecció o col·leccions següent(s)

Mostra el registre parcial de l'element

Cerca a RODERIC

Cerca avançada

Visualitza

Estadístiques