NAGIOS: RODERIC FUNCIONANDO

A feedback mechanism controls rDNA copy number evolution in yeast independently of natural selection

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

A feedback mechanism controls rDNA copy number evolution in yeast independently of natural selection

dc.contributor.author	Arnau Llombart, Vicente
dc.contributor.author	Barba-Aliaga, Marina
dc.contributor.author	Singh, Gaurav
dc.contributor.author	Ferri, Javier
dc.contributor.author	García Martínez, José
dc.contributor.author	Pérez Ortín, José Enrique
dc.date.accessioned	2022-09-02T13:03:56Z
dc.date.available	2022-09-02T13:03:56Z
dc.date.issued	2022
dc.identifier.citation	Arnau Llombart, Vicente Barba-Aliaga, Marina Singh, Gaurav Ferri, Javier García Martínez, José Pérez Ortín, José Enrique 2022 A feedback mechanism controls rDNA copy number evolution in yeast independently of natural selection Plos One 17 9 e0272878
dc.identifier.uri	https://hdl.handle.net/10550/83657
dc.description.abstract	Ribosomal DNA (rDNA) is the genetic loci that encodes rRNA in eukaryotes. It is typically arranged as tandem repeats that vary in copy number within the same species. We have recently shown that rDNA repeats copy number in the yeast Saccharomyces cerevisiae is controlled by cell volume via a feedback circuit that senses cell volume by means of the concentration of the free upstream activator factor (UAF). The UAF strongly binds the rDNA gene promoter, but is also able to repress SIR2 deacetylase gene transcription that, in turn, represses rDNA amplification. In this way, the cells with a smaller DNA copy number than what is optimal evolve to increase that copy number until they reach a number that sequestrates free UAF and provokes SIR2 derepression that, in turn, blocks rDNA amplification. Here we propose a mathematical model to show that this evolutionary process can amplify rDNA repeats independently of the selective advantage of yeast cells having bigger or smaller rDNA copy numbers. We test several variants of this process and show that it can explain the observed experimental results independently of natural selection. These results predict that an autoregulated feedback circuit may, in some instances, drive to non Darwinian deterministic evolution for a limited time period.
dc.language.iso	eng
dc.relation.ispartof	Plos One, 2022, vol. 17, num. 9, p. e0272878
dc.subject	Cicle cel·lular
dc.subject	Evolució (Biologia)
dc.subject	Selecció natural
dc.title	A feedback mechanism controls rDNA copy number evolution in yeast independently of natural selection
dc.type	journal article	es_ES
dc.date.updated	2022-09-02T13:03:56Z
dc.identifier.doi	10.1371/journal.pone.0272878
dc.identifier.idgrec	154604
dc.rights.accessRights	open access	es_ES