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Allogeneic Stem Cell Transplantation in Mantle Cell Lymphoma; Insights into Its Potential Role in the Era of New Immunotherapeutic and Targeted Therapies: The GETH/GELTAMO Experience

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Allogeneic Stem Cell Transplantation in Mantle Cell Lymphoma; Insights into Its Potential Role in the Era of New Immunotherapeutic and Targeted Therapies: The GETH/GELTAMO Experience

dc.contributor.author	Gutierrez, Antonio
dc.contributor.author	Bento, Leyre
dc.contributor.author	Novelli, Silvana
dc.contributor.author	Martin, Alejandro
dc.contributor.author	Gutierrez, Gonzalo
dc.contributor.author	Queralt Salas, Maria
dc.contributor.author	Bastos-Oreiro, Mariana
dc.contributor.author	Perez, Ariadna
dc.contributor.author	Hernani Morales, Rafael
dc.contributor.author	Cruz Viguria, Maria
dc.contributor.author	Lopez-Godino, Oriana
dc.contributor.author	Montoro, Juan
dc.contributor.author	Piñana, José Luis
dc.contributor.author	Ferra, Christelle
dc.contributor.author	Parody, Rocio
dc.contributor.author	Martin, Carmen
dc.contributor.author	Español, Ignacio
dc.contributor.author	Yañez, Lucrecia
dc.contributor.author	Rodriguez, Guillermo
dc.contributor.author	Zanabili, Joud
dc.contributor.author	Herrera, Pilar
dc.contributor.author	Varela, Maria Rosario
dc.contributor.author	Sampol Mayol, Antonia
dc.contributor.author	Solano Vercet, Carlos
dc.contributor.author	Caballero, Dolores
dc.date.accessioned	2022-09-06T10:01:51Z
dc.date.available	2022-09-06T10:01:51Z
dc.date.issued	2022
dc.identifier.citation	Gutierrez, Antonio Bento, Leyre Novelli, Silvana Martin, Alejandro Gutierrez, Gonzalo Queralt Salas, Maria Bastos-Oreiro, Mariana Perez, Ariadna Hernani Morales, Rafael Cruz Viguria, Maria Lopez-Godino, Oriana Montoro, Juan Piñana, Jose Luis Ferra, Christelle Parody, Rocio Martin, Carmen Español, Ignacio Yañez, Lucrecia Rodriguez, Guillermo Zanabili, Joud Herrera, Pilar Varela, Maria Rosario Sampol Mayol, Antonia Solano Vercet, Carlos Caballero, Dolores 2022 Allogeneic Stem Cell Transplantation in Mantle Cell Lymphoma; Insights into Its Potential Role in the Era of New Immunotherapeutic and Targeted Therapies: The GETH/GELTAMO Experience Cancers
dc.identifier.uri	https://hdl.handle.net/10550/83734
dc.description.abstract	Allo-SCT is a curative option for selected patients with relapsed/refractory (R/R) MCL, but with significant NRM. We present the long-term results of patients receiving allo-SCT in Spain from March 1995 to February 2020. The primary endpoints were EFS, OS, and cumulative incidence (CI) of NRM, relapse, and GVHD. We included 135 patients, most (85%) receiving RIC. After a median follow-up of 68 months, 5-year EFS and OS were 47 and 50%, respectively. Overall and CR rates were 86 and 80%. The CI of relapse at 1 and 3 years were 7 and 12%. NRM at day 100 and 1 year were 17 and 32%. Previous ASCT and Grade 3-4 aGVHD were associated with a higher NRM. Grade 3-4 aGVHD, donor type (mismatch non-related), and the time-period 2006-2020 were independently related to worse EFS. Patients from 1995-2005 were younger, most from HLA-identical sibling donors, and were pretreated less. Our data confirmed that allo-SCT may be a curative option in R/R MCL with low a CI of relapse, although NRM is still high, being mainly secondary to aGVHD. The arrival of new, highly effective and low toxic immunotherapeutic or targeted therapies inevitably will relegate allo-SCT to those fit patients who fail these therapies, far away from the optimal timing of treatment.
dc.language.iso	eng
dc.relation.ispartof	Cancers, 2022
dc.subject	Càncer
dc.title	Allogeneic Stem Cell Transplantation in Mantle Cell Lymphoma; Insights into Its Potential Role in the Era of New Immunotherapeutic and Targeted Therapies: The GETH/GELTAMO Experience
dc.type	journal article	es_ES
dc.date.updated	2022-09-06T10:01:51Z
dc.identifier.doi	10.3390/cancers14112673
dc.identifier.idgrec	154547
dc.rights.accessRights	open access	es_ES