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Ancient dental calculus preserves signatures of biofilm succession and interindividual variation independent of dental pathology

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Ancient dental calculus preserves signatures of biofilm succession and interindividual variation independent of dental pathology

dc.contributor.author	Velsko, Irina M.
dc.contributor.author	Semerau, Lena
dc.contributor.author	Inskip, Sarah A.
dc.contributor.author	García Collado, Maite I
dc.contributor.author	Ziesemer, Kirsten
dc.contributor.author	Serrano Ruber, María
dc.contributor.author	Benítez de Lugo Enrich, Luis
dc.contributor.author	Molero García, Jesús Manuel
dc.contributor.author	Gallego Valle, David
dc.contributor.author	Peña Ruiz, Ana Cristina
dc.contributor.author	Salazar García, Domingo Carlos
dc.contributor.author	Hoogland, Menno L.P.
dc.contributor.author	Warinner, Christina
dc.date.accessioned	2022-09-15T11:22:58Z
dc.date.available	2022-09-15T11:22:58Z
dc.date.issued	2022
dc.identifier.citation	Velsko, Irina M. Semerau, Lena Inskip, Sarah A. García Collado, Maite I Ziesemer, Kirsten Serrano Ruber, María Benítez de Lugo Enrich, Luis Molero García, Jesús Manuel Gallego Valle, David Peña Ruiz, Ana Cristina Salazar García, Domingo Carlos Hoogland, Menno L.P. Warinner, Christina 2022 Ancient dental calculus preserves signatures of biofilm succession and interindividual variation independent of dental pathology PNAS Nexus 1 4 1 14
dc.identifier.uri	https://hdl.handle.net/10550/83839
dc.description.abstract	Dental calculus preserves oral microbes, enabling comparative studies of the oral microbiome and health through time. However, small sample sizes and limited dental health metadata have hindered health-focused investigations to date. Here, we investigate the relationship between tobacco pipe smoking and dental calculus microbiomes. Dental calculus from 75 individuals from the 19th century Middenbeemster skeletal collection (Netherlands) were analyzed by metagenomics. Demographic and dental health parameters were systematically recorded, including the presence/number of pipe notches. Comparative data sets fromEuropean populations before and after the introduction of tobacco were also analyzed. Calculus species profiles were compared with oral pathology to examine associations between microbiome community, smoking behavior, and oral health status. The Middenbeemster individuals exhibited relatively poor oral health, with a high prevalence of periodontal disease, caries, heavy calculus deposits, and antemortem tooth loss. No associations between pipe notches and dental pathologies, or microbial species composition, were found. Calculus samples before and after the introduction of tobacco showed highly similar species profiles. Observed interindividual microbiome differences were consistent with previously described variation in human populations from the Upper Paleolithic to the present. Dental calculus may not preserve microbial indicators of health and disease status as distinctly as dental plaque.
dc.language.iso	eng
dc.relation.ispartof	PNAS Nexus, 2022, vol. 1, num. 4, p. 1-14
dc.subject	Restes humanes (Arqueologia)
dc.title	Ancient dental calculus preserves signatures of biofilm succession and interindividual variation independent of dental pathology
dc.type	journal article	es_ES
dc.date.updated	2022-09-15T11:22:58Z
dc.identifier.doi	10.1093/pnasnexus/pgac148
dc.identifier.idgrec	154707
dc.rights.accessRights	open access	es_ES