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Bionate biocompatibility: in vivo study in rabbits

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Bionate biocompatibility: in vivo study in rabbits

dc.contributor.author	Vanaclocha-Saiz, Amparo
dc.contributor.author	Vanaclocha Vanaclocha, Vicente
dc.contributor.author	Atienza Vicente, Carlos M.
dc.contributor.author	Jordá Gómez, P.
dc.contributor.author	Primo-Capella, Victor
dc.contributor.author	Barrios, Carlos
dc.contributor.author	Vanaclocha, Leyre
dc.date.accessioned	2022-09-20T07:37:32Z
dc.date.available	2022-09-20T07:37:32Z
dc.date.issued	2022
dc.identifier.citation	Vanaclocha-Saiz, Amparo Vanaclocha Vanaclocha, Vicente Atienza Vicente, Carlos M. Jordá Gómez, P. Primo-Capella, Victor Barrios, Carlos Vanaclocha, Leyre 2022 Bionate biocompatibility: in vivo study in rabbits Acs Omega 7 34 29647 29654
dc.identifier.uri	https://hdl.handle.net/10550/83871
dc.description.abstract	Response to foreign materials includes local tissue reaction, osteolysis, implant loosening, and migration to lymph nodes and organs. Bionate 80A human explants show minor wear and slight local tissue reaction, but we do not know the response at the spinal cord, nerve roots, lymph nodes, or distant organs. This study aims to figure out reactions against Bionate 80A when implanted at the spinal epidural space of 24 20-week-old New Zealand white rabbits. In one group of 12 rabbits, we implanted Bionate 80A on the spinal epidural space, and another group of 12 rabbits was used as the control group. We studied tissues, organs, and tissue damage markers on blood biochemistry, urine tests, and necropsy. The animals' clinical parameters and weight showed no statistically significant differences. At 3 months, the basophils increased slightly in the implant group, platelets decreased in all, and at 6 months, implanted animals showed slight eosinophilia, but none of these changes was statistically significant. External, organ, and spinal tissue examination showed neither toxic reaction, inflammatory changes, or noticeable differences between groups or survival periods. Under microscopic examination, the Bionate 80A particles induced a chronic granulomatous response always outside the dura mater, with giant multinucleated cells holding phagocytized particles and no particle migration to lymph nodes or organs. Thus, it was concluded that Bionate particles, when implanted in the rabbit lumbar epidural space, do not generate a significant reaction limited to the surrounding soft tissues with giant multinucleated cells. In addition, the particles did not cross the dura mater or migrate to lymph nodes or organs.
dc.language.iso	eng
dc.relation.ispartof	Acs Omega, 2022, vol. 7, num. 34, p. 29647-29654
dc.subject	Biomecànica
dc.title	Bionate biocompatibility: in vivo study in rabbits
dc.type	journal article	es_ES
dc.date.updated	2022-09-20T07:37:33Z
dc.identifier.idgrec	154731
dc.rights.accessRights	open access	es_ES