People with disabilities tend to have lower subjective well-being than their peers without disability. This study examined differences in the life satisfaction (LS) of Spanish university students with disabilities according to sociodemographic variables, and its associations with physical activity (PA) and athletic identity (AI). A crosssectional study was conducted with 1,227 participants (624 Female - 598 Male) from state and private Spanish universities. The participants completed an electronic survey on LS, PA and AI after which a descriptive analysis, pairwise comparisons (Mann-Whitney U, Kruskal-Wallis tests), and Spearman's correlations were performed on the data. Instruments used for data gathering were the Satisfaction With Life Scale (SWLS), the International Physical Activity Questionnaire (IPAQ) and the Athletic Identity Measurement Scale (AIMS). The results showed that university students with disabilities in Spain were slightly dissatisfied with their lives. The cross-sectional comparisons according to the origin of disability found that University students with congenital disability reported higher levels of LS than those with acquired disability. Those students with multiple disabilities and chronic illness reported lower levels of LS than students with physical or sensory disabilities. Furthermore, LS seemed not to be affected by gender while significatively affected by age since the youngest group of participants reported higher levels of LS than the middle and oldest groups. Both AI and PA were positively correlated with LS. The findings offered in this study point out that the satisfaction levels observed among students with disabilities suggest that universities and society at large were still disabling agents with an inherent need for improving their healthy lifestyles. This study provides insights that may be helpful for enhancing LS among university students with disabilities through promotion of PA.