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Presence of Blastocystis in the gut microbiota is associated with cognitive traits and decreased executive function

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Presence of Blastocystis in the gut microbiota is associated with cognitive traits and decreased executive function

dc.contributor.author	Mayneris-Perxachs, Jordi
dc.contributor.author	Arnoriaga-Rodríguez, María
dc.contributor.author	Garre-Olmo, Josep
dc.contributor.author	Puig, Josep
dc.contributor.author	Ramos Blanes, Rafael
dc.contributor.author	Trelis Villanueva, María
dc.contributor.author	Burokas, Aurelijus
dc.contributor.author	Coll, Clàudia
dc.contributor.author	Zapata-Tona, Cristina
dc.contributor.author	Pedraza, Salvador
dc.contributor.author	Pérez-Brocal, Vicente
dc.contributor.author	Ramió, Lluís
dc.contributor.author	Ricart, Wifredo
dc.contributor.author	Moya, Andrés
dc.contributor.author	Jové, Mariona
dc.contributor.author	Sol, Joaquim
dc.contributor.author	Portero-Otin, Manuel
dc.contributor.author	Pamplona, Reinald
dc.contributor.author	Maldonado, Rafael
dc.contributor.author	Fernández-Real, José Manuel
dc.date.accessioned	2022-10-10T13:24:51Z
dc.date.available	2022-10-10T13:24:51Z
dc.date.issued	2022
dc.identifier.citation	Mayneris-Perxachs, Jordi Arnoriaga-Rodríguez, María Garre-Olmo, Josep Puig, Josep Ramos Blanes, Rafael Trelis Villanueva, María Burokas, Aurelijus Coll, Clàudia Zapata-Tona, Cristina Pedraza, Salvador Pérez-Brocal, Vicente Ramió, Lluís Ricart, Wifredo Moya Simarro, Andrés Jové, Mariona Sol, Joaquim Portero-Otin, Manuel Pamplona, Reinald Maldonado, Rafael Fernández-Real, José Manuel 2022 Presence of Blastocystis in the gut microbiota is associated with cognitive traits and decreased executive function Isme Journal 16 9 2181 2197
dc.identifier.uri	https://hdl.handle.net/10550/84151
dc.description.abstract	Growing evidence implicates the gut microbiome in cognition. Blastocystis is a common gut single-cell eukaryote parasite frequently detected in humans but its potential involvement in human pathophysiology has been poorly characterized. Here we describe how the presence of Blastocystis in the gut microbiome was associated with deficits in executive function and altered gut bacterial composition in a discovery (n = 114) and replication cohorts (n = 942). We also found that Blastocystis was linked to bacterial functions related to aromatic amino acids metabolism and folate-mediated pyrimidine and one-carbon metabolism. Blastocystis-associated shifts in bacterial functionality translated into the circulating metabolome. Finally, we evaluated the effects of microbiota transplantation. Donor's Blastocystis subtypes led to altered recipient's mice cognitive function and prefrontal cortex gene expression. In summary, Blastocystis warrant further consideration as a novel actor in the gut microbiome-brain axis.
dc.language.iso	eng
dc.relation.ispartof	Isme Journal, 2022, vol. 16, num. 9, p. 2181-2197
dc.subject	Microbiologia
dc.subject	Aparell digestiu
dc.title	Presence of Blastocystis in the gut microbiota is associated with cognitive traits and decreased executive function
dc.type	journal article	es_ES
dc.date.updated	2022-10-10T13:24:52Z
dc.identifier.doi	10.1038/s41396-022-01262-3
dc.identifier.idgrec	154840
dc.rights.accessRights	open access	es_ES