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dc.contributor.author | Torres Ibáñez, José Manuel | |
dc.contributor.author | Pulido Murillo, Rafael | |
dc.date.accessioned | 2022-10-20T16:20:14Z | |
dc.date.available | 2022-10-20T16:20:14Z | |
dc.date.issued | 2001 | |
dc.identifier.citation | Torres Ibáñez, José Manuel Pulido Murillo, Rafael 2001 The Tumor Suppressor PTEN Is Phosphorylated by the Protein Kinase CK2 at Its C Terminus: IMPLICATIONS FOR PTEN STABILITY TO PROTEASOME-MEDIATED DEGRADATION Journal of Biological Chemistry 276 2 993 998 | |
dc.identifier.uri | https://hdl.handle.net/10550/84226 | |
dc.description.abstract | The tumor suppressor phosphatase PTEN regulates cell migration, growth, and survival by dephosphorylating phosphatidylinositol second messengers and signaling phosphoproteins. PTEN possesses a C-terminal noncatalytic regulatory domain that contains multiple putative phosphorylation sites, which could play an important role in the control of its biological activity. The protein kinase CK2 phosphorylated, in a constitutive manner, a cluster of Ser/Thr residues located at the PTEN C terminus. PTEN-phosphorylated defective mutants showed decreased stability in comparison with wild type PTEN and were more rapidly degraded by the proteasome. Inhibition of PTEN phosphorylation by the CK2 inhibitor 5,6-dichloro-1-β-d-ribofuranosyl-benzimidazole also diminished the PTEN protein content. Our results support the notion that proper phosphorylation of PTEN by CK2 is important for PTEN protein stability to proteasome-mediated degradation. | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Biological Chemistry, 2001, vol. 276, num. 2, p. 993-998 | |
dc.subject | Proteïnes supressores de tumors | |
dc.subject | Cèl·lules | |
dc.subject | Citologia | |
dc.title | The Tumor Suppressor PTEN Is Phosphorylated by the Protein Kinase CK2 at Its C Terminus: IMPLICATIONS FOR PTEN STABILITY TO PROTEASOME-MEDIATED DEGRADATION | |
dc.type | journal article | es_ES |
dc.date.updated | 2022-10-20T16:20:14Z | |
dc.identifier.doi | 10.1074/jbc.M009134200 | |
dc.identifier.idgrec | 080764 | |
dc.rights.accessRights | open access | es_ES |