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The Tumor Suppressor PTEN Is Phosphorylated by the Protein Kinase CK2 at Its C Terminus: IMPLICATIONS FOR PTEN STABILITY TO PROTEASOME-MEDIATED DEGRADATION

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The Tumor Suppressor PTEN Is Phosphorylated by the Protein Kinase CK2 at Its C Terminus: IMPLICATIONS FOR PTEN STABILITY TO PROTEASOME-MEDIATED DEGRADATION

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dc.contributor.author Torres Ibáñez, José Manuel
dc.contributor.author Pulido Murillo, Rafael
dc.date.accessioned 2022-10-20T16:20:14Z
dc.date.available 2022-10-20T16:20:14Z
dc.date.issued 2001
dc.identifier.citation Torres Ibáñez, José Manuel Pulido Murillo, Rafael 2001 The Tumor Suppressor PTEN Is Phosphorylated by the Protein Kinase CK2 at Its C Terminus: IMPLICATIONS FOR PTEN STABILITY TO PROTEASOME-MEDIATED DEGRADATION Journal of Biological Chemistry 276 2 993 998
dc.identifier.uri https://hdl.handle.net/10550/84226
dc.description.abstract The tumor suppressor phosphatase PTEN regulates cell migration, growth, and survival by dephosphorylating phosphatidylinositol second messengers and signaling phosphoproteins. PTEN possesses a C-terminal noncatalytic regulatory domain that contains multiple putative phosphorylation sites, which could play an important role in the control of its biological activity. The protein kinase CK2 phosphorylated, in a constitutive manner, a cluster of Ser/Thr residues located at the PTEN C terminus. PTEN-phosphorylated defective mutants showed decreased stability in comparison with wild type PTEN and were more rapidly degraded by the proteasome. Inhibition of PTEN phosphorylation by the CK2 inhibitor 5,6-dichloro-1-β-d-ribofuranosyl-benzimidazole also diminished the PTEN protein content. Our results support the notion that proper phosphorylation of PTEN by CK2 is important for PTEN protein stability to proteasome-mediated degradation.
dc.language.iso eng
dc.relation.ispartof Journal of Biological Chemistry, 2001, vol. 276, num. 2, p. 993-998
dc.subject Proteïnes supressores de tumors
dc.subject Cèl·lules
dc.subject Citologia
dc.title The Tumor Suppressor PTEN Is Phosphorylated by the Protein Kinase CK2 at Its C Terminus: IMPLICATIONS FOR PTEN STABILITY TO PROTEASOME-MEDIATED DEGRADATION
dc.type journal article es_ES
dc.date.updated 2022-10-20T16:20:14Z
dc.identifier.doi 10.1074/jbc.M009134200
dc.identifier.idgrec 080764
dc.rights.accessRights open access es_ES

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