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A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase

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A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase

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dc.contributor.author Blanco-Aparicio, Carmen
dc.contributor.author Torres Ibáñez, José Manuel
dc.contributor.author Pulido Murillo, Rafael
dc.date.accessioned 2022-11-03T14:27:04Z
dc.date.available 2022-11-03T14:27:04Z
dc.date.issued 1999
dc.identifier.citation Blanco-Aparicio, Carmen Torres Ibáñez, José Manuel Pulido Murillo, Rafael 1999 A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase Journal of Cell Biology 147 6 1129 1136
dc.identifier.uri https://hdl.handle.net/10550/84390
dc.description.abstract Protein tyrosine phosphatase PTP-SL retains mitogen-activated protein (MAP) kinases in the cytoplasm in an inactive form by association through a kinase interaction motif (KIM) and tyrosine dephosphorylation. The related tyrosine phosphatases PTP-SL and STEP were phosphorylated by the cAMP-dependent protein kinase A (PKA). The PKA phosphorylation site on PTP-SL was identified as the Ser231 residue, located within the KIM. Upon phosphorylation of Ser231, PTP-SL binding and tyrosine dephosphorylation of the MAP kinases extracellular signal-regulated kinase (ERK)1/2 and p38α were impaired. Furthermore, treatment of COS-7 cells with PKA activators, or overexpression of the Cα catalytic subunit of PKA, inhibited the cytoplasmic retention of ERK2 and p38α by wild-type PTP-SL, but not by a PTP-SL S231A mutant. These findings support the existence of a novel mechanism by which PKA may regulate the activation and translocation to the nucleus of MAP kinases.
dc.language.iso eng
dc.relation.ispartof Journal of Cell Biology, 1999, vol. 147, num. 6, p. 1129-1136
dc.subject Cèl·lules
dc.subject Enzims
dc.title A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase
dc.type journal article es_ES
dc.date.updated 2022-11-03T14:27:04Z
dc.identifier.doi 10.1083/jcb.147.6.1129
dc.identifier.idgrec 080762
dc.rights.accessRights open access es_ES

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