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Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substances

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Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substances

dc.contributor.author	Khantham, Chiranan
dc.contributor.author	Linsaenkart, Pichchapa
dc.contributor.author	Chaitep, Tanakarn
dc.contributor.author	Jantrawut, Pensark
dc.contributor.author	Chittasupho, Chuda
dc.contributor.author	Rachtanapun, Pornchai
dc.contributor.author	Jantanasakulwong, Kittisak
dc.contributor.author	Phimolsiripol, Yuthana
dc.contributor.author	Sommano, Sarana Rose
dc.contributor.author	Prom-u-thai, Chanakan
dc.contributor.author	Jamjod, Sansanee
dc.contributor.author	Arjin, Chaiwat
dc.contributor.author	Sringarm, Korawan
dc.contributor.author	Berrada Ramdani, Houda
dc.contributor.author	Barba Orellana, Francisco José
dc.contributor.author	Carmona, Francisco David
dc.contributor.author	Nimlamool, W.
dc.contributor.author	Ruksiriwanich, Wutigri
dc.date.accessioned	2022-11-28T15:02:51Z
dc.date.available	2022-11-28T15:02:51Z
dc.date.issued	2022
dc.identifier.citation	Khantham, Chiranan Linsaenkart, Pichchapa Chaitep, Tanakarn Jantrawut, Pensark Chittasupho, Chuda Rachtanapun, Pornchai Jantanasakulwong, Kittisak Phimolsiripol, Yuthana Sommano, Sarana Rose Prom-u-thai, Chanakan Jamjod, Sansanee Arjin, Chaiwat Sringarm, Korawan Berrada Ramdani, Houda Barba Orellana, Francisco José Carmona, Francisco David Nimlamool, W. Ruksiriwanich, Wutigri 2022 Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substances Plants-Basel 11(3) 330 1 18
dc.identifier.uri	https://hdl.handle.net/10550/84600
dc.description.abstract	Androgenetic alopecia (AGA), a hair loss disorder, is a genetic predisposition to sensitive androgens, inflammation, and oxidative stress. Unfortunately, current treatments with synthetic medicines contain a restricted mechanism along with side effects, whereas the bioactive constituents of plant extracts are multifunctional, with fewer side effects. The massive amounts of rice husk and bran are agricultural wastes that may cause pollution and environmental problems. Owing to these rationales, the local rice variety, Bue Bang 3 CMU (BB3CMU), which is grown in northern Thailand, was evaluated for the valuable utilization of rice by-products, husk (BB3CMU-H) and bran (BB3CMU-RB) extracts, for AGA treatment regarding antioxidant, anti-inflammatory, anti-androgenic activities, and the characterization of bioactive compounds. Our study verified that BB3CMU-H had the highest level of polyphenols, contributing to its greater antioxidant activity. Conversely, BB3CMU-RB was the predominant source of tocopherols, resulting in better anti-androgenic activities regarding the downregulation of steroid 5α-reductase genes (SRD5A). Notably, anti-inflammation via the attenuation of nitric oxide productions was observed in BB3CMU-H (0.06 ± 0.13 μM) and BB3CMU-RB (0.13 ± 0.01 μM), which were significantly comparable to diclofenac sodium salt (0.13 ± 0.19 μM). Therefore, the combination of BB3CMU-H and BB3CMU-RB could be utilized in cosmeceutical and pharmaceutical applications for AGA patients.
dc.language.iso	eng
dc.relation.ispartof	Plants-Basel, 2022, vol. 11(3), num. 330, p. 1-18
dc.subject	Cuir cabellut
dc.subject	Andrògens
dc.title	Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substances
dc.type	journal article	es_ES
dc.date.updated	2022-11-28T15:02:51Z
dc.identifier.doi	10.3390/plants11030330
dc.identifier.idgrec	151296
dc.rights.accessRights	open access	es_ES