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DNA methylation and non-coding RNAs during tissue-injury associated pain

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DNA methylation and non-coding RNAs during tissue-injury associated pain

dc.contributor.author	Irfan, Jahanzaib
dc.contributor.author	Febrianto, Muhammad Rizki
dc.contributor.author	Sharma, Anju
dc.contributor.author	Rose, Thomas
dc.contributor.author	Mahmudzade, Yasamin
dc.contributor.author	Di Giovanni, Simone
dc.contributor.author	Nagy, Istvan
dc.contributor.author	Torres-Perez, Jose V.
dc.date.accessioned	2022-12-12T14:58:02Z
dc.date.available	2022-12-12T14:58:02Z
dc.date.issued	2022
dc.identifier.citation	Irfan, Jahanzaib Febrianto, Muhammad Rizki Sharma, Anju Rose, Thomas Mahmudzade, Yasamin Di Giovanni, Simone Nagy, Istvan Torres-Perez, Jose V. 2022 DNA methylation and non-coding RNAs during tissue-injury associated pain International Journal Of Molecular Sciences 23 2 752
dc.identifier.uri	https://hdl.handle.net/10550/84724
dc.description.abstract	While about half of the population experience persistent pain associated with tissue damages during their lifetime, current symptom-based approaches often fail to reduce such pain to a satisfactory level. To provide better patient care, mechanism-based analgesic approaches must be developed, which necessitates a comprehensive understanding of the nociceptive mechanism leading to tissue injury-associated persistent pain. Epigenetic events leading the altered transcription in the nervous system are pivotal in the maintenance of pain in tissue injury. However, the mechanisms through which those events contribute to the persistence of pain are not fully understood. This review provides a summary and critical evaluation of two epigenetic mechanisms, DNA methylation and non-coding RNA expression, on transcriptional modulation in nociceptive pathways during the development of tissue injury-associated pain. We assess the pre-clinical data and their translational implication and evaluate the potential of controlling DNA methylation and non-coding RNA expression as novel analgesic approaches and/or biomarkers of persistent pain.
dc.language.iso	eng
dc.relation.ispartof	International Journal Of Molecular Sciences, 2022, vol. 23, num. 2, p. 752
dc.subject	RNA
dc.subject	Transcripció genètica
dc.subject	Neurociències
dc.title	DNA methylation and non-coding RNAs during tissue-injury associated pain
dc.type	journal article	es_ES
dc.date.updated	2022-12-12T14:58:02Z
dc.identifier.doi	10.3390/ijms23020752
dc.identifier.idgrec	155910
dc.rights.accessRights	open access	es_ES