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Organocatalytic enantioselective Mannich reaction of isoxazol-5(4H)-ones to isatin-derived ketimines

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Organocatalytic enantioselective Mannich reaction of isoxazol-5(4H)-ones to isatin-derived ketimines

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dc.contributor.author	Torán, Ricardo
dc.contributor.author	Puchán, Dario
dc.contributor.author	Sanz Marco, Amparo
dc.contributor.author	Vila Descals, Carlos
dc.contributor.author	Pedro, José Ramón
dc.contributor.author	Blay Llinares, Gonzalo
dc.date.accessioned	2022-12-13T14:41:57Z
dc.date.available	2022-12-13T14:41:57Z
dc.date.issued	2022
dc.identifier.citation	Torán, Ricardo Puchán, Dario Sanz Marco, Amparo Vila Descals, Carlos Pedro, José Ramón Blay Llinares, Gonzalo 2022 Organocatalytic enantioselective Mannich reaction of isoxazol-5(4H)-ones to isatin-derived ketimines Organic & Biomolecular Chemistry 20 43 8395 8399
dc.identifier.uri	https://hdl.handle.net/10550/84743
dc.description.abstract	An efficient organocatalytic asymmetric Mannich reaction between isoxazol-5(4H)-ones and isatin-derived ketimines has been developed. A bifunctional squaramide/Brønsted base organocatalyst catalyzed the enantioselective Mannich addition to afford chiral 3-aminooxindoles bearing a tetrasubstituted stereocenter at C3 decorated with an isoxazole moiety in good yields and with excellent enantioselectivities. Additionally, several synthetic transformations were described showing the versatility of the prepared compounds.
dc.language.iso	eng
dc.relation.ispartof	Organic & Biomolecular Chemistry, 2022, vol. 20, num. 43, p. 8395-8399
dc.subject	Catàlisi
dc.subject	Compostos heterocíclics
dc.subject	Química orgànica
dc.title	Organocatalytic enantioselective Mannich reaction of isoxazol-5(4H)-ones to isatin-derived ketimines
dc.type	journal article	es_ES
dc.date.updated	2022-12-13T14:41:57Z
dc.identifier.doi	10.1039/D2OB01692C
dc.identifier.idgrec	155525
dc.rights.accessRights	open access	es_ES