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baz1b loss-of-function in zebrafish produces phenotypic alterations consistent with the domestication syndrome

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baz1b loss-of-function in zebrafish produces phenotypic alterations consistent with the domestication syndrome

dc.contributor.author	Torres-Perez, Jose V.
dc.contributor.author	Anagianni, Sofia
dc.contributor.author	Mech, Aleksandra M.
dc.contributor.author	Havelange, William
dc.contributor.author	García-González, Judit
dc.contributor.author	Fraser, Scott E.
dc.contributor.author	Vallortigara, Giorgio
dc.contributor.author	Brennan, Caroline H.
dc.date.accessioned	2022-12-20T14:30:04Z
dc.date.available	2022-12-20T14:30:04Z
dc.date.issued	2023
dc.identifier.citation	Torres-Perez, Jose V. Anagianni, Sofia Mech, Aleksandra M. Havelange, William García-González, Judit Fraser, Scott E. Vallortigara, Giorgio Brennan, Caroline H. 2022 baz1b loss-of-function in zebrafish produces phenotypic alterations consistent with the domestication syndrome Iscience 26 1 105704
dc.identifier.uri	https://hdl.handle.net/10550/84828
dc.description.abstract	BAZ1B is an ubiquitously expressed nuclear protein with roles in chromatin remodelling, DNA replication and repair, and transcription. Reduced baz1b expression disrupts neuronal and neural crest development. Variation in the activity of baz1b has been proposed to underly morphological and behavioural aspects of domestication through disruption of neural crest development. Knockdown of baz1b in Xenopus embryos and Baz1b loss of function (LoF) in mice leads to craniofacial defects consistent with this hypothesis. We generated baz1b LoF zebrafish using CRISPR/Cas9 gene editing to test the hypothesis that baz1b regulates behavioural phenotypes associated with domestication in addition to craniofacial features. Zebrafish with baz1b LoF show mild under-development at larval stages and distinctive craniofacial features later in life. Mutant zebrafish show reduced anxiety-associated phenotypes and an altered ontogeny of social behaviours. Thus, in zebrafish, developmental deficits in baz1b recapitulate both morphological and behavioural phenotypes associated with the domestication syndrome in other species.
dc.language.iso	eng
dc.relation.ispartof	Iscience, 2022, vol. 26, num. 1, p. 105704
dc.subject	Neurociències
dc.subject	Peixos
dc.title	baz1b loss-of-function in zebrafish produces phenotypic alterations consistent with the domestication syndrome
dc.type	journal article	es_ES
dc.date.updated	2022-12-20T14:30:05Z
dc.identifier.doi	10.1016/j.isci.2022.105704
dc.identifier.idgrec	155911
dc.rights.accessRights	open access	es_ES