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Conductive polycaprolactone/gelatin/polyaniline nanofibres as functional scaffolds for cardiac tissue regeneration

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Conductive polycaprolactone/gelatin/polyaniline nanofibres as functional scaffolds for cardiac tissue regeneration

dc.contributor.author	Gil Castell, O.
dc.contributor.author	Ontoria-Oviedo, I.
dc.contributor.author	Badia Valiente, José David
dc.contributor.author	Amaro-Prellezo, E.
dc.contributor.author	Sepúlveda Sanchis, Pilar
dc.contributor.author	Ribes Greus, A.
dc.date.accessioned	2022-12-21T15:14:24Z
dc.date.available	2023-01-01T05:45:08Z
dc.date.issued	2022
dc.identifier.citation	Gil Castell, O. Ontoria-Oviedo, I. Badia Valiente, José David Amaro-Prellezo, E. Sepúlveda Sanchis, Pilar Ribes Greus, A. 2021 Conductive polycaprolactone/gelatin/polyaniline nanofibres as functional scaffolds for cardiac tissue regeneration Reactive & Functional Polymers 170 105064
dc.identifier.uri	https://hdl.handle.net/10550/84849
dc.description.abstract	The endorsement of functional features such as biocompatibility, mechanical integrity, or electrical conductivity to tissue engineering (TE) scaffolds is essential to stimulate cell adhesion and proliferation. In this study, electrospun nanofibers based on polycaprolactone (PCL) and gelatin (Ge) (ratios 60/40, 50/50, and 40/60), and polyaniline (PAni) particles (0.25, 0.50, and 1.00%wt) were prepared. The time of dissolution in an acid solvent mixture before electrospinning allowed for obtaining nanofibers with controlled features. Changes in the molar mass (Mn from 90·103 to 15·103 g·mol−1), in the crystalline microstructure (Xc from 60 to 25%) and the surface morphology (diameter from 250 to 50 nm) due to the controlled hydrolytic action on PCL were found. In vitro degradability and biocompatibility were favoured as the dissolution time and gelatin percentage increased. The presence of PAni was revealed as non-cytotoxic and promoted a controlled increase of the electrical conductivity, that contributed to in vitro cardiomyocyte proliferation. Cellular centres in the vicinities of PAni microparticles could be identified in the scaffold with the 40/60 PCL/Ge scaffold with PAni (1.00%wt), keeping the macrophages profile unaltered, which may determine the satisfactory resolution of cardiac injury and point out these scaffolds as appropriate candidates for cardiac TE.
dc.language.iso	eng
dc.relation.ispartof	Reactive & Functional Polymers, 2021, vol. 170, p. 105064
dc.subject	Solucions polimèriques
dc.subject	Semiconductors orgànics
dc.subject	Enginyeria biomèdica
dc.title	Conductive polycaprolactone/gelatin/polyaniline nanofibres as functional scaffolds for cardiac tissue regeneration
dc.type	journal article	es_ES
dc.date.updated	2022-12-21T15:14:24Z
dc.identifier.doi	10.1016/j.reactfunctpolym.2021.105064
dc.identifier.idgrec	155957
dc.embargo.terms	2 years
dc.rights.accessRights	open access	es_ES