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Identification of the gene repertoire of the IMD pathway and expression of antimicrobial peptide genes in several tissues and hemolymph of the cockroach Blattella germanica

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Identification of the gene repertoire of the IMD pathway and expression of antimicrobial peptide genes in several tissues and hemolymph of the cockroach Blattella germanica

dc.contributor.author	Zuber, Leo
dc.contributor.author	Domínguez-Santos, Rebeca
dc.contributor.author	García Ferris, Carlos
dc.contributor.author	Silva Moreno, Francisco J.
dc.date.accessioned	2023-01-09T14:05:17Z
dc.date.available	2023-01-09T14:05:17Z
dc.date.issued	2022
dc.identifier.citation	Zuber, Leo Domínguez-Santos, Rebeca García Ferris, Carlos Silva Moreno, Francisco J. 2022 Identification of the gene repertoire of the IMD pathway and expression of antimicrobial peptide genes in several tissues and hemolymph of the cockroach Blattella germanica International Journal Of Molecular Sciences 23 15 8444
dc.identifier.uri	https://hdl.handle.net/10550/84916
dc.description.abstract	Antimicrobial peptide (AMP) genes, triggered by Toll and IMD pathways, are essential components of the innate immune system in the German cockroach Blattella germanica. Besides their role in killing pathogenic bacteria, AMPs could be involved in controlling its symbiotic systems (endosymbiont and microbiota). We found that the IMD pathway was active in the adult female transcriptomes of six tissues (salivary glands, foregut, midgut, hindgut, Malpighian tubules and fat body) and hemolymph. Total expression of AMP genes was high in hemolymph and salivary glands and much lower in the other sample types. The expression of specific AMP genes was very heterogeneous among sample types. Two genes, defensin_g10 and drosomycin_g5, displayed relevant expression in the seven sample types, although higher in hemolymph. Other genes only displayed high expression in one tissue. Almost no expression of attacin-like and blattellicin genes was observed in any sample type, although some of them were among the genes with the highest expression in adult female whole bodies. The expression of AMP genes in salivary glands could help control pathogens ingested with food and even determine gut microbiota composition. The low expression levels in midgut and hindgut are probably related to the presence of beneficial microbiota. Furthermore, a reduction in the expression of AMP genes in fat body could be the way to prevent damage to the population of the endosymbiont Blattabacterium cuenoti within bacteriocytes.
dc.language.iso	eng
dc.relation.ispartof	International Journal Of Molecular Sciences, 2022, vol. 23, num. 15, p. 8444
dc.subject	Antibiòtics pèptids
dc.subject	Transcripció genètica
dc.subject	Resposta immunitària
dc.title	Identification of the gene repertoire of the IMD pathway and expression of antimicrobial peptide genes in several tissues and hemolymph of the cockroach Blattella germanica
dc.type	journal article	es_ES
dc.date.updated	2023-01-09T14:05:17Z
dc.identifier.doi	10.3390/ijms23158444
dc.identifier.idgrec	156180
dc.rights.accessRights	open access	es_ES