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Bioelectrical model of head-tail patterning based on cell ion channels and intercellular gap junctions

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Bioelectrical model of head-tail patterning based on cell ion channels and intercellular gap junctions

dc.contributor.author	Cervera Montesinos, Javier
dc.contributor.author	Meseguer, Salvador
dc.contributor.author	Levin, Michael
dc.contributor.author	Mafé, Salvador
dc.date.accessioned	2023-01-16T19:48:45Z
dc.date.available	2023-01-16T19:48:45Z
dc.date.issued	2020
dc.identifier.citation	Cervera Montesinos, Javier Meseguer, Salvador Levin, Michael Mafé, Salvador 2020 Bioelectrical model of head-tail patterning based on cell ion channels and intercellular gap junctions Bioelectrochemistry 132 107410-1 107410-12
dc.identifier.uri	https://hdl.handle.net/10550/84983
dc.description.abstract	Robust control of anterior-posterior axial patterning during regeneration is mediated by bioelectric signaling. However, a number of systems-level properties of bioelectrochemical circuits, including stochastic outcomes such as seen in permanently de-stabilized "cryptic" flatworms, are not completely understood. We present a bioelectrical model for head-tail patterning that combines single-cell characteristics such as membrane ion channels with multicellular community effects via voltage-gated gap junctions. It complements the biochemically-focused models by describing the effects of intercellular electrochemical coupling, cutting plane, and gap junction blocking of the multicellular ensemble. We provide qualitative insights into recent experiments concerning planarian anterior/posterior polarity by showing that: (i) bioelectrical signals can help separated cell domains to know their relative position after injury and contribute to the transitions between the abnormal double-head state and the normal head-tail state; (ii) the bioelectrical phase-space of the system shows a bi-stability region that can be interpreted as the cryptic system state; and (iii) context-dependent responses are obtained depending on the cutting plane position, the initial bioelectrical state of the multicellular system, and the intercellular connectivity. The model reveals how simple bioelectric circuits can exhibit complex tissue-level patterning and suggests strategies for regenerative control in vivo and in synthetic biology contexts.
dc.language.iso	eng
dc.relation.ispartof	Bioelectrochemistry, 2020, vol. 132, p. 107410-1-107410-12
dc.subject	Bioquímica
dc.subject	Cèl·lules
dc.title	Bioelectrical model of head-tail patterning based on cell ion channels and intercellular gap junctions
dc.type	journal article	es_ES
dc.date.updated	2023-01-16T19:48:46Z
dc.identifier.doi	10.1016/j.bioelechem.2019.107410
dc.identifier.idgrec	141744
dc.rights.accessRights	open access	es_ES