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Guava (Psidium guajava L.) leaf extract as bioactive substances for anti-androgen and antioxidant activities

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Guava (Psidium guajava L.) leaf extract as bioactive substances for anti-androgen and antioxidant activities

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dc.contributor.author Ruksiriwanich, Warintorn
dc.contributor.author Khantham, Chiranan
dc.contributor.author Muangsanguan, Anurak
dc.contributor.author Phimolsiripol, Yuthana
dc.contributor.author Barba Orellana, Francisco José
dc.contributor.author Sringarm, Korawan
dc.contributor.author Rachtanapun, Pornchai
dc.contributor.author Jantanasakulwong, Kittisak
dc.contributor.author Jantrawut, Pensak
dc.contributor.author Chittasupho, Chuda
dc.contributor.author Chutoprapat, Romchat
dc.contributor.author Boonpisuttinant, Korawinwich
dc.contributor.author Sommano, Sarana Rose
dc.date.accessioned 2023-02-17T07:38:45Z
dc.date.available 2023-02-17T07:38:45Z
dc.date.issued 2022
dc.identifier.citation Ruksiriwanich, Warintorn Khantham, Chiranan Muangsanguan, Anurak Phimolsiripol, Yuthana Barba Orellana, Francisco José Sringarm, Korawan Rachtanapun, Pornchai Jantanasakulwong, Kittisak Jantrawut, Pensak Chittasupho, Chuda Chutoprapat, Romchat Boonpisuttinant, Korawinwich Sommano, Sarana Rose 2022 Guava (Psidium guajava L.) leaf extract as bioactive substances for anti-androgen and antioxidant activities Plants-Basel 11(24) 3514
dc.identifier.uri https://hdl.handle.net/10550/85472
dc.description.abstract Leaves of guava (Psidium guajava L.) have been used in Thai folk medicine without any supporting evidence as a traditional herbal remedy for hair loss. Androgenetic alopecia (AGA) is chronic hair loss caused by effects of androgens in those with a genetic predisposition, resulting in hair follicle miniaturization. Our objectives were to provide the mechanistic assessment of guava leaf extract on gene expressions related to the androgen pathway in well-known in vitro models, hair follicle dermal papilla cells (HFDPC), and human prostate cancer cells (DU-145), and to determine its bioactive constituents and antioxidant activities. LC-MS analysis demonstrated that the main components of the ethanolic extract of guava leaves are phenolic substances, specifically catechin, gallic acid, and quercetin, which contribute to its scavenging and metal chelating abilities. The guava leaf extract substantially downregulated SRD5A1, SRD5A2, and SRD5A3 genes in the DU-145 model, suggesting that the extract could minimize hair loss by inhibiting the synthesis of a potent androgen (dihydrotestosterone). SRD5A suppression by gallic acid and quercetin was verified. Our study reveals new perspectives on guava leaf extract's anti-androgen properties. This extract could be developed as alternative products or therapeutic adjuvants for the treatment of AGA and other androgen-related disorders.
dc.language.iso eng
dc.relation.ispartof Plants-Basel, 2022, vol. 11(24), num. 3514
dc.subject Plantes medicinals
dc.title Guava (Psidium guajava L.) leaf extract as bioactive substances for anti-androgen and antioxidant activities
dc.type journal article es_ES
dc.date.updated 2023-02-17T07:38:46Z
dc.identifier.doi 10.3390/plants11243514
dc.identifier.idgrec 156914
dc.rights.accessRights open access es_ES

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