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Molecular and Clinical Predictors of Quality of Life in Chronic Rhinosinusitis with Nasal Polyps

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Molecular and Clinical Predictors of Quality of Life in Chronic Rhinosinusitis with Nasal Polyps

dc.contributor.author	Brunet García, Aina
dc.contributor.author	Milara Payá, Javier
dc.contributor.author	Frías Moya-Angeler, M Soledad
dc.contributor.author	Cortijo Gimeno, Julio
dc.contributor.author	Armengot Carceller, Miguel
dc.date.accessioned	2023-03-07T15:21:42Z
dc.date.available	2023-03-07T15:21:42Z
dc.date.issued	2023
dc.identifier.citation	Brunet García, Aina Milara Payá, Javier Frías Moya-Angeler, M Soledad Cortijo Gimeno, Julio Armengot Carceller, Miguel 2023 Molecular and Clinical Predictors of Quality of Life in Chronic Rhinosinusitis with Nasal Polyps Journal Of Clinical Medicine Feb 9;12(4):139
dc.identifier.uri	https://hdl.handle.net/10550/85703
dc.description.abstract	Factors influencing the quality of life (QoL) of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) are poorly understood. We set out to determine the predictive factors on patients' QoL using the Sino-Nasal Outcome Test-22 (SNOT-22); (2) Methods: An ambispective analysis of data from patients diagnosed with CRSwNP in our institution. All the patients underwent a nasal polyp biopsy and completed the SNOT-22 questionnaire. Demographic and molecular data as well as the SNOT-22 scores were collected. Patients were classified in six subgroups considering the presence of asthma, non-steroidal drugs (NSAID) intolerance and corticosteroid resistance; (3) Results: The mean SNOT-22 score was 39. Considering the clinical parameters, the SNOT-22 value was significantly associated with NSAID intolerance (p = 0.04) and the endoscopic polyp score (p = 0.04). A high SNOT-22 value was also correlated with high tissue eosinophilia (p = 0.01) and high IL-8 expression; (4) Conclusions: Eosinophilia, IL-8 expression and NSAID intolerance can be used as predictors of worse QoL in patients with CRSwNP.
dc.language.iso	eng
dc.relation.ispartof	Journal Of Clinical Medicine, 2023, vol. Feb 9;12(4):139
dc.subject	Infeccions respiratòries
dc.title	Molecular and Clinical Predictors of Quality of Life in Chronic Rhinosinusitis with Nasal Polyps
dc.type	journal article	es_ES
dc.date.updated	2023-03-07T15:21:42Z
dc.identifier.doi	10.3390/jcm12041391
dc.identifier.idgrec	157039
dc.rights.accessRights	open access	es_ES