Corporate social irresponsibility (CSI) is a critical issue for managers and researchers. In fact, the number of studies on this subject from diverse literature is rapidly increasing, seeking to answer questions regarding the core elements of CSI, its antecedents, and consequences. This paper offers a comprehensive literature review of this topic, identifying and assessing previous studies, synthesizing their findings, and highlighting knowledge gaps. Additionally, it offers recommendations regarding how to move forward. Our review identified 155 studies published from 1962 to 2020 that describe the antecedents, outcomes, mediators, and moderators of CSI according to different levels of analysis. We contribute to the social issues in management literature in that we analyze the facilitators and inhibitors of CSI and the consequences for firms using a multilevel approach. Finally, we provide guidance for future research by assessing the core elements that define the level of irresponsibility—harm to others and intentionality.