NAGIOS: RODERIC FUNCIONANDO

Thresholds of handgrip strength for all-cause, Cancer, and cardiovascular mortality : a systematic review with dose-response meta-analysis

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Thresholds of handgrip strength for all-cause, Cancer, and cardiovascular mortality : a systematic review with dose-response meta-analysis

dc.contributor.author	López Bueno, Rubén
dc.contributor.author	Andersen, Lars Louis
dc.contributor.author	Koyanagi, Ai
dc.contributor.author	Núñez Cortés, Rodrigo
dc.contributor.author	Calatayud Villalba, Joaquín
dc.contributor.author	Casaña Granell, José
dc.contributor.author	del Pozo Cruz, Borja
dc.date.accessioned	2023-04-25T16:20:58Z
dc.date.available	2023-04-25T16:20:58Z
dc.date.issued	2022
dc.identifier.citation	López Bueno, Rubén Andersen, Lars Louis Koyanagi, Ai Núñez Cortés, Rodrigo Calatayud Villalba, Joaquín Casaña Granell, José del Pozo Cruz, Borja 2022 Thresholds of handgrip strength for all-cause, Cancer, and cardiovascular mortality : a systematic review with dose-response meta-analysis Ageing Research Reviews
dc.identifier.uri	https://hdl.handle.net/10550/86166
dc.description.abstract	While handgrip strength is associated with all-cause and cause-specific mortality, whether such associations are dose-dependent is largely unknown. Therefore, we conducted a systematic review on the dose-response relationship of handgrip strength with all-cause mortality, cancer, and cardiovascular mortality. The data source included three electronic databases (PubMed/MEDLINE, Web of Science and Scopus) from inception to 8 February 2022. Prospective cohort studies of healthy adults with objective measures of handgrip strength were included. Two researchers independently screened studies, extracted data, and assessed risk of bias. We used estimates regarding handgrip strength categories to conduct a random forest model, and a two-stage random-effects hierarchical meta-regression model pooling study-specific estimates for dose-response relationship. Outcomes included all-cause, cancer, and cardiovascular mortality. orty-eight studies comprising 3,135,473 participants (49.6% women, age range 35-85 years) were included. Random forest models showed a significant inverse association between handgrip strength and all-cause and cause-specific mortality. Dose-response meta-analyses showed that higher levels of handgrip strength significantly reduced the risk of all-cause mortality within 26-50 kg (Higgin´s I2 =45.7%) in a close-to-linear inverse fashion. Cancer and cardiovascular mortality displayed a trend towards a U-shaped association with a significant risk reduction between 16 and 33 kg (Higgin´s I2 =77.4%), and a close-to-linear inverse shaped and significant risk reduction ranging from 24 to 40 kg (Higgin´s I2 =79.7%) respectively. There is strong evidence for an association between lower handgrip strength with higher all-cause, cancer, and cardiovascular mortality risk. The dose-response relationship of handgrip strength substantially varies depending on the cause of mortality.
dc.language.iso	eng
dc.relation.ispartof	Ageing Research Reviews, 2022
dc.subject	Avaluació del risc
dc.subject	Salut pública
dc.title	Thresholds of handgrip strength for all-cause, Cancer, and cardiovascular mortality : a systematic review with dose-response meta-analysis
dc.type	journal article
dc.date.updated	2023-04-25T16:20:58Z
dc.identifier.doi	10.1016/j.arr.2022.101778
dc.identifier.idgrec	157861
dc.rights.accessRights	open access