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Longitudinal association of handgrip Strength with all-cause and cardiovascular mortality in older adults using a causal framework

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Longitudinal association of handgrip Strength with all-cause and cardiovascular mortality in older adults using a causal framework

dc.contributor.author	López Bueno, Rubén
dc.contributor.author	Andersen, Lars Louis
dc.contributor.author	Calatayud Villalba, Joaquín
dc.contributor.author	Casaña Granell, José
dc.contributor.author	Smith, Lee
dc.contributor.author	Jacob, Louis
dc.contributor.author	Koyanagi, Ai
dc.contributor.author	López Gil, José Francisco
dc.contributor.author	del Pozo Cruz, Borja
dc.date.accessioned	2023-04-25T18:05:48Z
dc.date.available	2023-04-25T18:05:48Z
dc.date.issued	2022
dc.identifier.citation	López Bueno, Rubén Andersen, Lars Louis Calatayud Villalba, Joaquín Casaña Granell, José Smith, Lee Jacob, Louis Koyanagi, Ai López Gil, José Francisco del Pozo Cruz, Borja 2022 Longitudinal association of handgrip Strength with all-cause and cardiovascular mortality in older adults using a causal framework Experimental Gerontology
dc.identifier.uri	https://hdl.handle.net/10550/86171
dc.description.abstract	To date, there is no study addressing the time-varying confounding bias in the association of handgrip strength (HGS) with all-cause or cardiovascular mortality. Therefore, we conducted marginal structural models (MSM) to provide causal estimations on the associations of HGS with all-cause and cardiovascular mortality in a representative sample of adults aged 50 years or older. Data from 29 countries including 121,116 participants (276,994 observations; mean age 63.7 years; 56.3 % women) free from prior heart attack or stroke were retrieved from consecutive waves of the Survey of Health, Ageing and Retirement in Europe (SHARE). During a median of 7.7 years follow-up (interquartile range 3.8-11.8) and 1,009,862 person-years, 6407 participants (5.3 %) died due to all causes, and 2263 (1.9 %) died due to cardiovascular diseases. Using repeated measures of handheld dynamometry, we determined absolute and relative to body mass index HGS of each participant. We applied adjusted MSM to estimate hazard ratios (HRs) associated with changes over time in HGS addressing the time-varying confounding bias. An increase of 5 kg in HGS was associated with a reduced risk of all-cause [HR 0.86, 95 % confidence interval (CI), 0.86-0.90], overall cardiovascular (HR 0.86, 95 % CI 0.82-0.86), heart attack (HR 0.90, 95 % CI 0.86-0.95), and stroke (HR 0.86, 95 % CI 0.82-0.90) mortality. The associations of relative HGS were of stronger magnitude in all cases. Our findings provide critical evidence on the importance of increasing general muscle strength in older adults to reduce mortality risk, particularly concerning cardiovascular causes.
dc.language.iso	eng
dc.relation.ispartof	Experimental Gerontology, 2022
dc.subject	Exercici
dc.subject	Educació física per a persones grans
dc.title	Longitudinal association of handgrip Strength with all-cause and cardiovascular mortality in older adults using a causal framework
dc.type	journal article
dc.date.updated	2023-04-25T18:05:48Z
dc.identifier.doi	10.1016/j.exger.2022.111951
dc.identifier.idgrec	157865
dc.rights.accessRights	open access