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Vicarious social defeat increases conditioned rewarding effects of cocaine and ethanol intake in female mice.

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Vicarious social defeat increases conditioned rewarding effects of cocaine and ethanol intake in female mice.

dc.contributor.author	Ródenas González, Francisco
dc.contributor.author	Arenas Fenollar, M. Carmen
dc.contributor.author	Blanco Gandía, María del Carmen
dc.contributor.author	Manzanedo Pérez, Carmen
dc.contributor.author	Rodríguez Arias, Marta
dc.date.accessioned	2023-04-28T08:28:16Z
dc.date.available	2023-04-28T08:28:16Z
dc.date.issued	2023
dc.identifier.citation	Ródenas González, Francisco Arenas Fenollar, M. Carmen Blanco Gandía, María del Carmen Manzanedo Pérez, Carmen Rodríguez Arias, Marta 2023 Vicarious social defeat increases conditioned rewarding effects of cocaine and ethanol intake in female mice. Biomedicines 11 2 502
dc.identifier.uri	https://hdl.handle.net/10550/86238
dc.description.abstract	Stress is a critical factor in the development of mood and drug use disorders. The social defeat model is not appropriate for female rodents due to their low level of aggression. Therefore, a robust female model of social stress needs to be developed and validated. The aim of the present study was to unravel the long-lasting effects of vicarious social defeat (VSD) on the conditioned rewarding effects of cocaine and ethanol intake in female mice. Although VSD seems to be a good model for inducing behavioral and physiologic endophenotypes induced by stress, there are no studies to date that characterize the effect of VSD on cocaine or alcohol use. The results confirm that VSD females showed an increase in corticosterone levels after a vicarious experience while also displaying an increase in anxiety- and anhedonic-like behaviors. Three weeks after the last VSD, vicariously defeated female mice showed an increased developed preference for a non-effective dose of cocaine in the conditioned place preference (CPP) paradigm and showed an increase in ethanol intake. Our results suggest that female mice vicariously experience a state of distress through the social observation of others suffering from adverse events, confirming the use of VSD as a valid model to study the response to social stress in females. The fact that VSD in females induced a comparable behavioral phenotype to that observed in physically defeated males could indicate a relationship with the higher rate of psychopathologies observed in women. Notwithstanding, more studies are needed to dissect the neurobiological and behavioral peculiarities of the female response to social stress.
dc.language.iso	eng
dc.relation.ispartof	Biomedicines, 2023, vol. 11, num. 2, p. 502
dc.subject	Estrès
dc.subject	Drogues
dc.subject	Alcohol
dc.title	Vicarious social defeat increases conditioned rewarding effects of cocaine and ethanol intake in female mice.
dc.type	journal article
dc.date.updated	2023-04-28T08:28:16Z
dc.identifier.doi	10.3390/biomedicines11020502
dc.identifier.idgrec	158012
dc.rights.accessRights	open access