The model of Person-Centred Care has as fundamental principles the emphasis on the person within its context, individualized attention and empowerment. However, studies about this approach on mental illness are scarce. The aim of this work is to carry out a systematic review of articles studying the approach of Person-Centered Care provided by professional caregivers in people with mental illness. To this end, a systematic review according to PRISMA guidelines was carried out of articles found in the Web of Science (WoS), PubMed, ScienceDirect and Dialnet databases. Following the analysis of the 19 articles, the results show that both users and professionals perceive that Person-Centered Care carries positive results for people who use it. Greater information provision is needed for users and caregivers, in an understandable way, a greater emphasis on the relationships between services and users, as well as better training for professionals.