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Knowledge gaps and future directions in cognitive functions in children and adolescents with primary arterial hypertension : A systematic review

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Knowledge gaps and future directions in cognitive functions in children and adolescents with primary arterial hypertension : A systematic review

dc.contributor.author	Lucas, Ignacio
dc.contributor.author	Puteikis, Kristijonas
dc.contributor.author	Sinha, Manish D.
dc.contributor.author	Litwin, Mieczysław
dc.contributor.author	Merkevicius, Kajus
dc.contributor.author	Azukaitis, Karolis
dc.contributor.author	Rus, Rina
dc.contributor.author	Pac, Michał
dc.contributor.author	Obrycki, Lukasz
dc.contributor.author	Bårdsen, Tonje
dc.contributor.author	Sladowska Kozlowska, Joanna
dc.contributor.author	Sagsak, Elif
dc.contributor.author	Lurbe i Ferrer, Empar
dc.contributor.author	Jiménez Murcia, Susana
dc.contributor.author	Jankauskiené, Augustina
dc.contributor.author	Fernández Aranda, Fernando
dc.date.accessioned	2023-05-02T17:53:09Z
dc.date.available	2023-05-02T17:53:09Z
dc.date.issued	2022
dc.identifier.citation	Lucas, Ignacio Puteikis, Kristijonas Sinha, Manish D. Litwin, Mieczys&#322aw Merkevicius, Kajus Azukaitis, Karolis Rus, Rina Pac, Micha&#322 Obrycki, Lukasz Bårdsen, Tonje Sladowska Kozlowska, Joanna Sagsak, Elif Lurbe i Ferrer, Empar Jiménez Murcia, Susana Jankauskiené, Augustina Fernández Aranda, Fernando 2022 Knowledge gaps and future directions in cognitive functions in children and adolescents with primary arterial hypertension : A systematic review Frontiers In Cardiovascular Medicine 9 973793 973793
dc.identifier.uri	https://hdl.handle.net/10550/86287
dc.description.abstract	Arterial hypertension (AH) among adults is known to be associated with worse cognitive outcomes. Similarly, children and adolescents with AH could be expected to underperform during neuropsychological evaluations when compared with healthy peers. Our aims were to review the existing literature on cognitive functioning among children and adolescents with primary AH and to identify what additional evidence may be needed to substantiate the impact of hypertension on poor cognitive outcomes in this population. We conducted a systematic review of articles in PubMed and Web of Science published before 17 January 2022, reporting on cognitive testing among children and adolescents with primary AH. From 1,316 records, 13 were included in the review-7 used battery-testing while other employed indirect measures of cognitive functions. Most of the studies reported worse results among individuals with AH. Results of two prospective trials suggested that cognitive functioning may improve after starting antihypertensive treatment. Ambulatory blood pressure monitoring was shown to be more strongly related to cognitive testing results than office measures of blood pressure. Significant confounders, namely obesity and sleep apnea, were identified throughout the studies. Our review indicates that evidence relating AH with poor cognitive functioning among youth is usually based on indirect measures of executive functions (e.g., questionnaires) rather than objective neuropsychological tests. Future prospective trials set to test different cognitive domains in children and adolescents undergoing treatment for AH are endorsed and should consider using standardized neuropsychological batteries as well as adjust the assessing results for obesity and sleep disorders.
dc.language.iso	eng
dc.relation.ispartof	Frontiers In Cardiovascular Medicine, 2022, num. 9, p. 973793-973793
dc.subject	Pressió sanguínia
dc.subject	Infants
dc.subject	Joves
dc.title	Knowledge gaps and future directions in cognitive functions in children and adolescents with primary arterial hypertension : A systematic review
dc.type	journal article
dc.date.updated	2023-05-02T17:53:10Z
dc.identifier.doi	10.3389/fcvm.2022.973793
dc.identifier.idgrec	157962
dc.rights.accessRights	open access