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Meshless electrophysiological modelling of cardiac resynchronization therapy - Benchmark analysis with finite-element methods in experimental data

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Meshless electrophysiological modelling of cardiac resynchronization therapy - Benchmark analysis with finite-element methods in experimental data

dc.contributor.author	Albors, C.
dc.contributor.author	Lluch, E.
dc.contributor.author	Gomez, J.F.
dc.contributor.author	Cedilnik, N.
dc.contributor.author	Mountris, K.A.
dc.contributor.author	Mansi, T.
dc.contributor.author	Khamzin, S.
dc.contributor.author	Dokuchaev, A.
dc.contributor.author	Solovyova, O.
dc.contributor.author	Pueyo, E.
dc.contributor.author	Sermesant, M.
dc.contributor.author	Sebastián Aguilar, Rafael
dc.contributor.author	Morales, H.
dc.contributor.author	Camara, Óscar
dc.date.accessioned	2023-05-12T16:16:35Z
dc.date.available	2023-05-12T16:16:35Z
dc.date.issued	2022
dc.identifier.citation	Albors, C. Lluch, E. Gomez, J.F. Cedilnik, N. Mountris, K.A. Mansi, T. Khamzin, S. Dokuchaev, A. Solovyova, O. Pueyo, E. Sermesant, M. Sebastian Aguilar, Rafael Morales, H. Camara, Óscar 2022 Meshless electrophysiological modelling of cardiac resynchronization therapy - Benchmark analysis with finite-element methods in experimental data Applied Sciences 12 6438 1 27
dc.identifier.uri	https://hdl.handle.net/10550/86581
dc.description.abstract	Computational models of cardiac electrophysiology are promising tools for reducing the rates of non-response patients suitable for cardiac resynchronization therapy (CRT) by optimizing electrode placement. The majority of computational models in the literature are mesh-based, primarily using the finite element method (FEM). The generation of patient-specific cardiac meshes has traditionally been a tedious task requiring manual intervention and hindering the modeling of a large number of cases. Meshless models can be a valid alternative due to their mesh quality independence. The organization of challenges such as the CRT-EPiggy19, providing unique experimental data as open access, enables benchmarking analysis of different cardiac computational modeling solutions with quantitative metrics. We present a benchmark analysis of a meshless-based method with finite-element methods for the prediction of cardiac electrical patterns in CRT, based on a subset of the CRT-EPiggy19 dataset. A data assimilation strategy was designed to personalize the most relevant parameters of the electrophysiological simulations and identify the optimal CRT lead configuration. The simulation results obtained with the meshless model were equivalent to FEM, with the most relevant aspect for accurate CRT predictions being the parameter personalization strategy (e.g., regional conduction velocity distribution, including the Purkinje system and CRT lead distribution).
dc.language.iso	eng
dc.relation.ispartof	Applied Sciences, 2022, vol. 12, num. 6438, p. 1-27
dc.subject	Potencials evocats (Electrofisiologia)
dc.subject	Informàtica
dc.title	Meshless electrophysiological modelling of cardiac resynchronization therapy - Benchmark analysis with finite-element methods in experimental data
dc.type	journal article
dc.date.updated	2023-05-12T16:16:37Z
dc.identifier.doi	10.3390/app12136438
dc.identifier.idgrec	158452
dc.rights.accessRights	open access