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Genistein effect on cognition in prodromal Alzheimer's disease patients : the GENIAL clinical trial

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Genistein effect on cognition in prodromal Alzheimer's disease patients : the GENIAL clinical trial

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Viña Ribes, José; Escudero, Joaquín; Baquero, Miquel; Cebrián, Mónica; Carbonell Asíns, Juan Antonio; Muñoz Cebriá, José Enrique; Satorres Pons, Encarnación; Meléndez Moral, Juan Carlos; Ferrer Rebolleda, José; Cozar Santiago, Maria del Puig; Santabárbara Gómez, José Manuel; Jové, Mariona; Pamplona, Reinald; Tarazona Santabalbina, Francisco José; Borrás Blasco, Consuelo
Aquest document és un/a article, creat/da en: 2022

Delaying the transition from minimal cognitive impairment to Alzheimer's dementia is a major concern in Alzheimer's disease (AD) therapeutics. Pathological signs of AD occur years before the onset of clinical dementia. Thus, long-term therapeutic approaches, with safe, minimally invasive, and yet effective substances are recommended. There is a need to develop new drugs to delay Alzheimer's dementia. We have taken a nutritional supplement approach with genistein, a chemically defined polyphenol that acts by multimodal specific mechanisms. Our group previously showed that genistein supplementation is effective to treat the double transgenic (APP/PS1) AD animal model.
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