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Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice.

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Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice.

dc.contributor.author	Sanz Ros, Jorge
dc.contributor.author	Romero García, Nekane
dc.contributor.author	Mas Bargues, Cristina
dc.contributor.author	Monleón Salvadó, Daniel
dc.contributor.author	Gordevicius, Juozas
dc.contributor.author	Brooke, Robert
dc.contributor.author	Dromant Jarque, M. Mar
dc.contributor.author	Díaz Cuevas, Ana
dc.contributor.author	Derevyanko, Aksinya
dc.contributor.author	Guío Carrión, Ana
dc.contributor.author	Román Domínguez, Aurora
dc.contributor.author	Inglés de la Torre, Marta
dc.contributor.author	Blasco, María Ángeles
dc.contributor.author	Horvath, Steve
dc.contributor.author	Viña Ribes, José
dc.contributor.author	Borrás Blasco, Consuelo
dc.date.accessioned	2023-05-15T17:56:08Z
dc.date.available	2023-05-15T17:56:08Z
dc.date.issued	2022
dc.identifier.citation	Sanz Ros, Jorge Romero García, Nekane Mas Bargues, Cristina Monleón Salvado, Daniel Gordevicius, Juozas Brooke, Robert Dromant Jarque, M. Mar Díaz Cuevas, Ana Derevyanko, Aksinya Guío Carrión, Ana Román Domínguez, Aurora Inglés de la Torre, Marta Blasco, María Ángeles Horvath, Steve Viña Ribes, José Borrás Blasco, Consuelo 2022 Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice. Science Advances 8 42 eabq2226
dc.identifier.uri	https://hdl.handle.net/10550/86618
dc.description.abstract	Aging is associated with an increased risk of frailty, disability, and mortality. Strategies to delay the degenerative changes associated with aging and frailty are particularly interesting. We treated old animals with small extracellular vesicles (sEVs) derived from adipose mesenchymal stem cells (ADSCs) of young animals, and we found an improvement in several parameters usually altered with aging, such as motor coordination, grip strength, fatigue resistance, fur regeneration, and renal function, as well as an important decrease in frailty. ADSC-sEVs induced proregenerative effects and a decrease in oxidative stress, inflammation, and senescence markers in muscle and kidney. Moreover, predicted epigenetic age was lower in tissues of old mice treated with ADSC-sEVs and their metabolome changed to a youth-like pattern. Last, we gained some insight into the microRNAs contained in sEVs that might be responsible for the observed effects. We propose that young sEV treatment can promote healthy aging.
dc.language.iso	eng
dc.relation.ispartof	Science Advances, 2022, vol. 8, num. 42, p. eabq2226
dc.subject	Persones grans
dc.subject	Mortalitat
dc.subject	Discapacitat física
dc.title	Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice.
dc.type	journal article
dc.date.updated	2023-05-15T17:56:09Z
dc.identifier.doi	10.1126/sciadv.abq2226
dc.identifier.idgrec	155570
dc.rights.accessRights	open access