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BD MAX Enteric Bacterial, Bacterial Plus, and Virus Panels for Diagnosis of Acute Infectious Gastroenteritis: a Cost-Benefit Analysis

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BD MAX Enteric Bacterial, Bacterial Plus, and Virus Panels for Diagnosis of Acute Infectious Gastroenteritis: a Cost-Benefit Analysis

dc.contributor.author	Ferrer, Josep
dc.contributor.author	Giménez, Estela
dc.contributor.author	Carretero, Diego
dc.contributor.author	Buesa Gómez, Francisco Javier
dc.contributor.author	Morillas Jurado, Francisco Gabriel
dc.contributor.author	Granell Pérez, Rafael
dc.contributor.author	Fuenmayor Fernández, Amadeo
dc.contributor.author	Navarro, David
dc.contributor.author	Albert, Eliseo
dc.date.accessioned	2023-05-16T16:47:12Z
dc.date.available	2023-05-16T16:47:12Z
dc.date.issued	2022
dc.identifier.citation	Ferrer, Josep Giménez, Estela Carretero, Diego Buesa Gómez, Francisco Javier Morillas Jurado, Francisco Gabriel Granell Pérez, Rafael Fuenmayor Fernández, Amadeo Navarro, David Albert, Eliseo 2022 BD MAX Enteric Bacterial, Bacterial Plus, and Virus Panels for Diagnosis of Acute Infectious Gastroenteritis: a Cost-Benefit Analysis Microbiology Spectrum 10 5 1 9
dc.identifier.uri	https://hdl.handle.net/10550/86656
dc.description.abstract	Economic assessment is required to gauge the value of implementing PCR syndromic platforms in the microbiology laboratory for the diagnosis of community-acquired acute gastroenteritis (AGE) in pediatric and adult in- and outpatients. A cost-benefit analysis was conducted from a health care system perspective using BD MAX Enteric Bacterial, Bacterial Plus, and Virus panels. Two 6-month periods were selected, in which either conventional procedures (in 2017) or BD MAX PCR multiplex panels (in 2018) were used. We retrospectively reviewed medical records of all patients with positive results and a representative sample of negative ones. A Markov model was used to represent transition probabilities between different health care states from time of stool microbiological study until completion of AGEepisode-associated health care. A total of 1,336 medical records were reviewed (829 in 2018 and 507 in 2017), showing overall a significantly higher positivity rate in 2018 than in 2017 (26% versus 6%, P , 0.001). The total cost per individual associated with health care for AGE was e314 in 2018 and e341 in 2017; when we only considered the pediatric cohort, the figures were e271 and e456, respectively. Using Tornado sensitivity analyses, we found that the three variables that most influenced the model in descending order of weight were the probability of longer hospital stays, the probability of returning to the emergency room (ER), and the probability of hospitalization from the ER. Use of BD MAX enteric PCR platforms for the diagnosis of community-acquired AGE instead of a non-PCR-based conventional approach results in an incremental benefit from a health care perspective in the general population, particularly children.
dc.language.iso	eng
dc.relation.ispartof	Microbiology Spectrum, 2022, vol. 10, num. 5, p. 1-9
dc.subject	Tracte gastrointestinal Malalties
dc.subject	Anàlisi financera
dc.title	BD MAX Enteric Bacterial, Bacterial Plus, and Virus Panels for Diagnosis of Acute Infectious Gastroenteritis: a Cost-Benefit Analysis
dc.type	journal article
dc.date.updated	2023-05-16T16:47:13Z
dc.identifier.idgrec	155951
dc.rights.accessRights	open access