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Between Scylla and Charibdis: eIF2alpha kinases as targets for cancer chemotherapy.

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Between Scylla and Charibdis: eIF2alpha kinases as targets for cancer chemotherapy.

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dc.contributor.author Moreno Torres, Marta
dc.contributor.author Murguía, José Ramón
dc.date.accessioned 2023-05-22T08:19:56Z
dc.date.available 2023-05-22T08:19:56Z
dc.date.issued 2011
dc.identifier.citation Moreno Torres, Marta Murguía, José Ramón 2011 Between Scylla and Charibdis: eIF2alpha kinases as targets for cancer chemotherapy. Clinical & Translational Oncology 13 442 445
dc.identifier.uri https://hdl.handle.net/10550/86757
dc.description.abstract The eIF2α kinases integrate translation initiation rates with nutrient availability, thus allowing cells to adapt to nutrient scarcity. Recent evidence has uncovered new functions of these kinases in tumour cell biology, ranging from regulation of cell cycle progression, maintenance of genome stability, control of apoptosis, and cell survival under nutrient stress and hypoxia. Accordingly, active eIF2α kinases modulate the antineoplasic activity of several antitumour drugs, either by exacerbating their cytotoxic effect or by promoting chemoresistance. Understanding of eIF2α kinases molecular roles may provide mechanistic insights into how tumour cells sense and adapt to nutrient restriction, thus helping to implement more effective approaches for cancer chemotherapy.
dc.language.iso eng
dc.relation.ispartof Clinical & Translational Oncology, 2011, vol. 13, p. 442-445
dc.subject Bioquímica
dc.subject Biologia
dc.title Between Scylla and Charibdis: eIF2alpha kinases as targets for cancer chemotherapy.
dc.type journal article
dc.date.updated 2023-05-22T08:19:56Z
dc.identifier.doi 10.1007/s12094-011-0680-3
dc.identifier.idgrec 158858
dc.rights.accessRights open access

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