The Research Topic "Effect of Neurophysiological Conditions and Mental Workload on Physical and Cognitive Performances: a Multidimensional Perspective" compiles recent advances in the multidimensional assessment of the effect of neurophysiological status and mental workload on physical and cognitive performance (Aghajani et al., 2017; Perpetuini et al., 2022). Due to technological and data analytics tool advancements, non-invasive and real-time monitoring of the activity of the human central and autonomic nervous systems is now possible, facilitating the quantification of the relationship between physiology and human performance (Ashkanasy, 2004; Cardone et al., 2022). Moreover, questionnaires, whose scores highly correlate with physiological responses (Noyes and Bruneau, 2007; Perpetuini et al., 2021), could be administered to assess the psychological conditions of individuals during the execution of various tasks