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PTEN Deletion in Adult Mice Induces Hypoinsulinemia With Concomitant Low Glucose Levels

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PTEN Deletion in Adult Mice Induces Hypoinsulinemia With Concomitant Low Glucose Levels

dc.contributor.author	Crespo Masip, María
dc.contributor.author	Pérez Gómez, Aurora
dc.contributor.author	Guzmán, Carla
dc.contributor.author	Rayego, Sandra
dc.contributor.author	Doladé, Nuria
dc.contributor.author	García Carrasco, Alicia
dc.contributor.author	Jover Atienza, Ramiro
dc.contributor.author	Valdivielso, Jose Manuel
dc.date.accessioned	2023-05-29T10:38:28Z
dc.date.available	2023-05-29T10:38:28Z
dc.date.issued	2022
dc.identifier.citation	Crespo Masip, María Pérez Gómez, Aurora Guzmán, Carla Rayego, Sandra Doladé, Nuria García Carrasco, Alicia Jover Atienza, Ramiro Valdivielso, Jose Manuel 2022 PTEN Deletion in Adult Mice Induces Hypoinsulinemia With Concomitant Low Glucose Levels Frontiers In Endocrinology 13 1 13
dc.identifier.uri	https://hdl.handle.net/10550/87036
dc.description.abstract	The PI3K/AKT pathway, negatively regulated by PTEN, plays a paramount role in glucose metabolism regulation due to its activation by the insulin receptor signaling pathway. We generated a PTEN-KO mouse to evaluate the systemic effect of the overactivation of the PI3K/AKT pathway in insulin signaling and glucose homeostasis. Our results demonstrate that PTEN-KO mice show very low glucose levels in the fasted state, which poorly respond to glucose and pyruvate administration. Insulinemia decreased without alterations in pancreatic islets. Among the possible reasons, we uncover the deregulation of the expression of proximal tubule glucose transporter and consequent glycosuria. Moreover, we evidence an altered activation of hepatic gluconeogenesis-related genes. In addition, the expression of several genes related to β-oxidation showed a delayed or even absent response to fasting, suggesting that the lack of PTEN not only impairs glucose metabolism but also slows down the use of lipids as a metabolic fuel. We conclude that the inducible full PTEN-KO mice could be a good model to study the metabolic interactions between glycidic and lipidic metabolism in hypoinsulinemic hypoglycemia and that PTEN could be an important mediator in the disease and/or a potential drug target.
dc.language.iso	eng
dc.relation.ispartof	Frontiers In Endocrinology, 2022, vol. 13, p. 1-13
dc.subject	Bioquímica
dc.subject	Biologia
dc.title	PTEN Deletion in Adult Mice Induces Hypoinsulinemia With Concomitant Low Glucose Levels
dc.type	journal article
dc.date.updated	2023-05-29T10:38:28Z
dc.identifier.doi	10.3389/fendo.2022.850214
dc.identifier.idgrec	159248
dc.rights.accessRights	open access