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Multi-omics HeCaToS dataset of repeated dose toxicity for cardiotoxic & hepatotoxic compounds.

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Multi-omics HeCaToS dataset of repeated dose toxicity for cardiotoxic & hepatotoxic compounds.

dc.contributor.author	Castell, José V.
dc.contributor.author	Verheijen, Marcha
dc.contributor.author	Sarkans, Ugis
dc.contributor.author	Jennen, Danyel
dc.contributor.author	Caiment, Florian
dc.contributor.author	Kleinjans, Jos
dc.contributor.author	Wolski, Witold
dc.date.accessioned	2023-05-31T11:23:41Z
dc.date.available	2023-05-31T11:23:41Z
dc.date.issued	2022
dc.identifier.citation	Castell Ripoll, José Vicente Verheijen, Marcha Sarkans, Ugis Jennen, Danyel Caiment, Florian Kleinjans, Jos Wolski, Witold 2022 Multi-omics HeCaToS dataset of repeated dose toxicity for cardiotoxic & hepatotoxic compounds. Scientific Data 9 699 1 11
dc.identifier.uri	https://hdl.handle.net/10550/87180
dc.description.abstract	The data currently described was generated within the EU/FP7 HeCaToS project (Hepatic and Cardiac Toxicity Systems modeling). The project aimed to develop an in silico prediction system to contribute to drug safety assessment for humans. For this purpose, multi-omics data of repeated dose toxicity were obtained for 10 hepatotoxic and 10 cardiotoxic compounds. Most data were gained from in vitro experiments in which 3D microtissues (either hepatic or cardiac) were exposed to a therapeutic (physiologically relevant concentrations calculated through PBPK-modeling) or a toxic dosing profile (IC20 after 7 days). Exposures lasted for 14 days and samples were obtained at 7 time points (therapeutic doses: 2-8-24-72-168-240-336 h; toxic doses 0-2-8-24-72-168-240 h). Transcriptomics (RNA sequencing & microRNA sequencing), proteomics (LC-MS), epigenomics (MeDIP sequencing) and metabolomics (LC-MS & NMR) data were obtained from these samples. Furthermore, functional endpoints (ATP content, Caspase3/7 and O2 consumption) were measured in exposed microtissues. Additionally, multi-omics data from human biopsies from patients are available. This data is now being released to the scientific community through the BioStudies data repository (https://www.ebi.ac.uk/biostudies/).
dc.language.iso	eng
dc.relation.ispartof	Scientific Data, 2022, vol. 9, num. 699, p. 1-11
dc.subject	Bioquímica
dc.subject	Biologia
dc.title	Multi-omics HeCaToS dataset of repeated dose toxicity for cardiotoxic & hepatotoxic compounds.
dc.type	journal article
dc.date.updated	2023-05-31T11:23:41Z
dc.identifier.doi	10.1038/s41597-022-01825-1
dc.identifier.idgrec	159553
dc.rights.accessRights	open access