To the Editor, A 22-year-old man with common variable immunodeficiency complicated by granulomatous-lymphocytic interstitial lung disease previously treated with azathioprine and a 4-weekly course of rituximab 3 years earlier who was receiving subcutaneous immunoglobulin replacement therapy was diagnosed with coronavirus disease 2019 (COVID-19) using an RT-PCR for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) of a nasopharyngeal swab specimen after a 4-day history of fever. He quarantined at home but was later admitted to the hospital with COVID-19 bilateral pneumonia and hypoxaemia on day 20. He was treated with ceftriaxone, dexamethasone and an extra dose of subcutaneous immunoglobulin replacement therapy, and was discharged on day 27 with positive RT-PCR assay of a nasopharyngeal swab (Ct value 30.1, Fig. 1, Fig. 2b). The patient did not develop a serological response ... [Llegir més ...]