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A chitosan/silica hybrid 3D scaffold for simultaneous entrapment of two different hydrophilic substances

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A chitosan/silica hybrid 3D scaffold for simultaneous entrapment of two different hydrophilic substances

dc.contributor.author	Elzayat, Asmaa M.
dc.contributor.author	Pérez Pla, Francisco Fernando
dc.contributor.author	Muñoz Espí, Rafael
dc.date.accessioned	2023-06-15T07:03:24Z
dc.date.available	2023-06-16T04:45:06Z
dc.date.issued	2022	es_ES
dc.identifier.citation	Elzayat, A. M., Pérez-Pla, F. F., & Munoz-Espi, R. (2022). A chitosan/silica hybrid 3D scaffold for simultaneous entrapment of two different hydrophilic substances. Materials Letters, 326, 132941.	es_ES
dc.identifier.uri	https://hdl.handle.net/10550/87906
dc.description.abstract	We report the preparation of a hybrid chitosan/silica three-dimensional (3D) scaffold loaded simultaneously with two model hydrophilic substances, ibuprofen sodium salt and erioglaucine disodium salt. The first substance is entrapped in situ during the preparation of chitosan submillimetric beads by ionotropic gelation with sodium triphosphate, while the latter is post-loaded during the scaffold formation. Controlled release experiments carried out under neutral conditions demonstrate that the presence of nanostructured silica within the polymer matrix retards the release of both hydrophilic substances and increases the structure stability of the scaffold. Release profiles can be fitted to a two-component model with a diffusion-controlled term (Korsmeyer-Peppas model), which dominates the release of the post-loaded substance, and a second swelling/erosion term, which becomes relevant for the in situ entrapped drug.	es_ES
dc.language.iso	en	es_ES
dc.publisher	Elsevier	es_ES
dc.subject	biopolymer	es_ES
dc.subject	chitosan	es_ES
dc.subject	silica	es_ES
dc.subject	hybrid	es_ES
dc.subject	scaffold	es_ES
dc.subject	drug release	es_ES
dc.title	A chitosan/silica hybrid 3D scaffold for simultaneous entrapment of two different hydrophilic substances	es_ES
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS TECNOLÓGICAS	es_ES
dc.identifier.doi	10.1016/j.matlet.2022.132941	es_ES
dc.accrualmethod	CI	es_ES
dc.embargo.terms	0 days	es_ES
dc.type.hasVersion	VoR	es_ES
dc.rights.accessRights	open access	es_ES