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Comparison of the whole slide imaging and conventional light microscopy in the grading of oral epithelial dysplasia:a multi-institutional study

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Comparison of the whole slide imaging and conventional light microscopy in the grading of oral epithelial dysplasia:a multi-institutional study

dc.contributor.author	Diniz, Priscilla Barbosa	es
dc.contributor.author	Sena-Filho, Marcondes	es
dc.contributor.author	Graner, Karen Mendes	es
dc.contributor.author	Mariz, Bruno A.L.A.	es
dc.contributor.author	dos Reis, Leonardo Amaral	es
dc.contributor.author	Almeida, Oslei Paes de	es
dc.contributor.author	Jorge, Jacks	es
dc.date.accessioned	2023-06-16T08:36:36Z
dc.date.available	2023-06-16T08:36:36Z
dc.date.issued	2021	es
dc.identifier.citation	Diniz, PB., Sena-Filho, M., Graner, KM., Mariz, BA., Reis, LA., Almeida, OP., & Jorge, J. (2021). Comparison of the whole slide imaging and conventional light microscopy in the grading of oral epithelial dysplasia: a multi-institutional study. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e8-e13). Medicina Oral, S.L. https://doi.org/10.4317/medoral.23854	es
dc.identifier.uri	https://hdl.handle.net/10550/87986
dc.description.abstract	Whole Slide Imaging (WSI) is an alternative method to light microscopy (LM). However, few studies have compared the diagnostic agreement between WSI and LM, especially to grade oral epithelial dysplasia (OED). The purpose of this study was to evaluate the variability in grading OED by the World Health Organization grading system, using WSI and conventional LM, and to investigate whether the access to clinical information, and psychologic or physical states of the pathologists could interfere with the diagnosis. eleven experienced pathologists from seven Brazilian universities independently evaluated twenty-five OED cases. The analyses were performed in duplicate for each method, with an interval of at least 30 days, and the time consumed in each analysis was measured. Physical and psychologic states were evaluated by blood pressure levels, heart rate and two questionnaires: State-Trait Anxiety Inventory and Perceived Stress Scale. Clinical information was provided after the second evaluation using WSI and the pathologist could change their diagnostic decision or not. LM showed a higher inter-examiner agreement (k=0.53) than WSI (k=0.45) and a smaller time consumed by the pathologists (mean of 65.53 seconds compared to 91.02 seconds in WSI). In the first analysis using conventional microscopy, there was a positive correlation between kappa values and anxiety (r=0.47, p=0.02), and stress (r=0.64, p<0.01), and an inverse correlation with heart rate (r=-0.48, p=0.02). In the digital analysis, there was also a positive correlation between kappa values and anxiety (r=0.75, p<0.001). After clinical information was given, there was a slight change in 11.3% of the cases, and a great discrepancy in 1.1% of the cases, mainly increasing the OED grade. both microscopy systems had similar results, although LM had slightly higher kappa values, and WSI was more time consuming.	es
dc.subject	photobiomodulation	es
dc.subject	head and neck neoplasms	es
dc.subject	radiotherapy	es
dc.subject	xerostomia	es
dc.subject	saliva	es
dc.title	Comparison of the whole slide imaging and conventional light microscopy in the grading of oral epithelial dysplasia:a multi-institutional study	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.23854	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806346/