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Does anti-inflammatory drugs modify the severe odontogenic infection prognosis? A 10-year?s experience

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Does anti-inflammatory drugs modify the severe odontogenic infection prognosis? A 10-year?s experience

dc.contributor.author	Delbet-Dupas, Candice	es
dc.contributor.author	Devoize, Laurent	es
dc.contributor.author	Mulliez, Aurélien	es
dc.contributor.author	Barthélémy, Isabelle	es
dc.contributor.author	Pham-Dang, Nathalie	es
dc.date.accessioned	2023-06-16T08:36:36Z
dc.date.available	2023-06-16T08:36:36Z
dc.date.issued	2021	es
dc.identifier.citation	Delbet-Dupas, C., Devoize, L., Mulliez, A., Barthélémy, I., & Pham Dang, N. (2021). Does anti-inflammatory drugs modify the severe odontogenic infection prognosis? A 10-year’s experience. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e28-e35). Medicina Oral, S.L. https://doi.org/10.4317/medoral.23926	es
dc.identifier.uri	https://hdl.handle.net/10550/87989
dc.description.abstract	Numerous biochemical datas support the noxious role of anti-inflammatory drugs on immune response. Those observations are often put forward for unfavorable evolution of odontogenic infection but has never been really proven in clinic. The aim of this study is to try to clarify this role based on the collection of the clinical course of odontogenic infections over a 10-year analysis period. The investigators implemented a prospective observational study. The sample was composed of patients managed between January 2004 and December 2014 for severe odontogenic infection based on three criteria: hospital admission, intravenous antibiotic therapy, tooth extraction and collections drainage under general anesthesia. Clinical and pharmacological data were collected at admission, during hospitalization until discharged home. The population was first separated into two groups patients with or without anti-inflammatory drugs on admission, then on four groups (non-steroidal anti-inflammatory drugs, corticosteroids drugs, both and none on admission). Analysis were performed each time by univariate analysis, multivariate analysis and propensity score matching. Six hundred and fifty-three patients were included in the study, 329 (50%) patients report orally anti-inflammatory treatment before presenting to hospital, 50 (7.6%) received corticosteroids, 242 (37%) received NSAIDs and 37 (5.6%) both. Evolution is worsening for patients under anti-inflammatory drugs in term of hospitalization in ICU (p=0.016), number of surgeries (p=0.003), risk of tracheotomy (p=0.036), duration of hospitalization (p=0.005) and spaces involved by the infection (p<0.001). When separating patients into 4 groups, dysphonia and odynophagia are more frequent for patients under corticosteroid and NSAID (35.14%, p<0.001), mediastinal erythema is more frequent for patients under corticosteroid (16%, p=0.004), fever is more frequent for patients under NSAID (35.5%, p=0.032), pain is higher for patients under corticosteroids (p=0.024). But, in order to reduce bias, linked to factors of gravity, a regression weighted by propensity scores was performed and any group of patients is different from the others. Patients under anti-inflammatory drugs have more severe dental infection on admission and their complex evolution seems to be linked to the severity of infection on admission.	es
dc.subject	lip	es
dc.subject	tumor	es
dc.subject	neoplasm	es
dc.subject	carcinoma	es
dc.subject	cyst	es
dc.title	Does anti-inflammatory drugs modify the severe odontogenic infection prognosis? A 10-year?s experience	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.23926	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806345/