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Effects of preemptive analgesia with intravenous acetaminophen on postoperative pain relief in patients undergoing third molar surgery:a prospective, single-blind, randomized controlled trial

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Effects of preemptive analgesia with intravenous acetaminophen on postoperative pain relief in patients undergoing third molar surgery:a prospective, single-blind, randomized controlled trial

dc.contributor.author	Kano, Keita	es
dc.contributor.author	Kawamura, Kahori	es
dc.contributor.author	Miyake, Tatsuro	es
dc.date.accessioned	2023-06-16T08:36:37Z
dc.date.available	2023-06-16T08:36:37Z
dc.date.issued	2021	es
dc.identifier.citation	Kano, K., Kawamura, K., & Miyake, T. (2021). Effects of preemptive analgesia with intravenous acetaminophen on postoperative pain relief in patients undergoing third molar surgery: a prospective, single-blind, randomized controlled trial. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e64-e70). Medicina Oral, S.L. https://doi.org/10.4317/medoral.23983	es
dc.identifier.uri	https://hdl.handle.net/10550/87994
dc.description.abstract	The efficacy of preemptive analgesia in managing postoperative pain remains controversial. The aim of this study was to compare the efficacy of intravenous (IV) acetaminophen administered before or immediately after the surgical extraction of an impacted mandibular third molar. This prospective randomized clinical trial included 120 patients. The patients were assigned to one of three groups: the preoperative-treatment group (pre-group), which received 1000 mg of IV acetaminophen 20 min before surgery; the postoperative-treatment group (post-group), which received 1000 mg of IV acetaminophen after surgery; the no-treatment group (control-group), which did not receive any analgesic. Rescue analgesic (60 mg loxoprofen) was issued to each patient, with instructions on self-administration if needed. For the rescue medication usage, the time of first loxoprofen usage and the total amount of loxoprofen consumption were obtained for a 17-hour period after surgery. We measured pain using the visual analogue scale at 1 hour and at 2, 3, 4, 5, and 15 hours after surgery. There was no significant difference in pain level among the three groups at any time interval. However, the pre-group demonstrated significantly lower rescue analgesic consumption and longer time until initial administration. Administration of IV acetaminophen before third molar surgery provides more effective pain control than postoperative administration and no treatment.	es
dc.subject	primary sjögren's syndrome	es
dc.subject	mucin	es
dc.subject	muc7	es
dc.subject	muc5b	es
dc.subject	muc1	es
dc.subject	sulphate oligosaccharides	es
dc.title	Effects of preemptive analgesia with intravenous acetaminophen on postoperative pain relief in patients undergoing third molar surgery:a prospective, single-blind, randomized controlled trial	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.23983	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806347/